Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1991-08-01
1993-04-06
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435197, 436149, C12Q 146, C12N 918, G01N 1518
Patent
active
052003248
ABSTRACT:
A method is provided for the screening of senile dementia of the Alzheimer type (Alzheimer's disease) by testing for an anomalous molecular form of acetylcholinesterase in cerebrospinal fluid of a patient.
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Smith and Cuello, "Alzheimer's disease and acetylcholinesterase containing neurons," Lancet 1984; ii:513.
Chubb, I. W. et al, "Is acetylcholinesterase secreted from central neurons into cerebrospinal fluid?" Neuroscience 1976; 1:57-62.
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Davies, P., "Neurotransmitter-related enzymes in senile dementia of the Alzheimer type," Brain Res. 1979, 171:319-327.
Soininen et al, "Acetylcholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type," Acta Neurol. Scand. 1981, 64:217-224.
Appleyard et al, "Decrease CSF acetylcholinesterase activity in Alzheimer's disease," Lancet 1983, ii:452.
Appleyard et al, "Cholinesterase activities in cerebrospinal fluid of patients with senile dementia of the Alzheimer types," Brain 1987, 110:1309-1322.
Arendt et al, "Decreased ratio of CSF acetylcholinesterase to butyrylcholinesterase activity in Alzheimer's disease," Lancet 1984, i:173.
Jobst Kim A.
McDonald Brendon I.
Navaratnam Dasakumar S.
Priddle John D.
Smith A. David
Brown Johnnie R.
E. R. Squibb & Sons Inc.
Rodney Burton
Varma A.
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