Method of diagnosing risk of myocardial infarction by...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07745137

ABSTRACT:
It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained.

REFERENCES:
patent: 2004/0005566 (2004-01-01), DePhillipo et al.
patent: 2005/0026169 (2005-02-01), Cargill et al.
patent: 2005/0089914 (2005-04-01), Yamasaki
patent: 2007/0042382 (2007-02-01), Cargill et al.
patent: WO-91/13075 (1991-09-01), None
patent: WO-01/18250 (2001-03-01), None
patent: WO-01/79234 (2001-10-01), None
patent: WO-03/087360 (2003-10-01), None
Terashima et al., Circulation 99, 2717-2719 (1999).
M.E. Marenberg, et al.; “Genetic Susceptibility to Death From Coronary Heart Disease in a Study of Twins;”The New England Journal of Medicine; vol. 330; No. 15; Apr. 14, 1994; pp. 1041-1046.
J.J. Nora, et al:; “Genetic-Epidemiologic Study of Early-onset Ischemic Heart Disease;”Circulation; vol. 61; No. 3; Mar. 1980; pp. 503-508.
U. Broeckel, et al.; “A comprehensive linkage analysis for myocardial infarction and its related risk factors;”Nature Genetics; vol. 30; Feb. 2002; pp. 210-214.
F. Cambien, et al.; “Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction;”Nature; vol. 359; Oct. 15, 1992; pp. 641-644.
E. J. Weiss, et al; “A Polymorphism of a Platelet Glycoprotein Receptor as an Inherited Risk Factor for Coronary Thrombosis;”The New England Journal of Medicine; vol. 334; No. 17; Apr. 25, 1996; pp. 1090-1094.
L. Iacoviello, et al.; “Polymorphisms in the Coagulation Factor VII Gene and the Risk of Myocardial Infarction;”The New England Journal of Medicine; vol. 338; No. 2; Jan. 8, 1998; pp. 79-85.
J.A. Kuivenhoven, et al., “The Role of a Common Variant of the Cholesterol Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis;”The New England Journal of Medicine; vol. 338; No. 2; Jan. 8, 1998; pp. 86-93.
M. Boerma, et al.; “A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development;”Journal of Internal Medicine; vol. 246; 1999; pp. 211-218.
N. Inoue, et al.; “Polymorphism of the NADH/NADPH Oxidasep22 phoxGene in Patients With Coronary Artery Disease;”Circulation; vol. 97; 1998; pp. 135-137.
E.J. Topol, et al; “Single Nucleotide Polymorphisms in Multiple Novel Thrombospondin Genes May Be Associated With Familial Premature Myocardial Infarction;”Circulation; vol. 104; Nov. 27, 2001; pp. 2641-2644.
T. Skoog, et al.; “A common functional polymorphism (C→A substitution at position-863) in the promotor region of the tumour necrosis factor-α (TNF-α) gene associated with reduced circulating levels of TNF-α;”Human Molecular Genetics; vol. 8; No. 8; 1999; pp. 1443-1449.
Y. Yamada, et al.; “Identification of the G994→T Missense Mutation in Exon 9 of the Plasma Platelet-Activating Factor Acetylhydrolase Gene as an Independent Risk Factor for Coronary Artery Disease in Japanese Men;”Metabolism; vol. 47; No. 2; Feb. 1998; pp. 177-181.
W. Koch, et al.; “Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction;”Artherosclerosis; vol. 159; 2001; pp. 137-144.
I. Inoue, et al.; “A Nucleotide Substitution in the Promotor of Human Angiotensinogen Is Associated with Essential Hypertension and Affects Basal Transcription In Vitro;”J. Clin. Invest; vol. 99; No. 7; Apr. 1997; pp. 1786-1797.
J.-C. Lambert, et al.; “Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations-the ECTIM study;”Human Molecular Genetics; vol. 9; No. 1; 2000; pp. 57-61.
M. Eto, et al.; “Increased frequencies of apolipoprotein ε2 and ε4 alleles in patients with ischemic schemic heart disease;”Clinical Genetics; vol. 36; 1989; pp. 183-188.
J. Ruiz, et al.; “Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes;”The Lancet; vol. 346; Sep. 30, 1995; pp. 869-872.
M. Murata, et al.; “Coronary Artery Disease and Polymorphisms in a Receptor Mediating Shear Stress-Dependent Platelet Activation;”Circulation; vol. 96; No. 10; Nov. 18, 1997; pp. 3281-3286.
P. Eriksson, et al.; “Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction;”Proc. Natl. Acad. Sci. USA; vol. 92; Mar. 1995; pp. 1851-1855.
S. Ye, et al.; “Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis;”Br Heart J; vol. 73; 1995; pp. 209-215.
R.W. Mahley; “Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology;”Science; vol. 240; Apr. 29, 1988; pp. 622-630.
W.J. Schneider, et al.; “Familial Dysbetalipoproteinemia. Abnormal Binding of Mutant Apoprotein E to Low Density Lipoprotein Receptors of Human Fibroblasts and Membranes from Liver and Adrenal of Rats, Rabbits, and Cows;”J. Clin. Invest.; vol. 68; Nov. 1981; pp. 1075-1085.
R.E. Gregg, et al.; “Type III Hyperlipoproteinemia: Defective Metabolism of an Abnormal Apolipoprotein E;”Science; vol. 211; Feb. 6, 1981; pp. 584-586.
J.L. Breslow, et al.; “Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2;”Journal of Lipid Research; vol. 23; 1982; pp. 1224-1235.
P.M. Sullivan, et al.; “Type III Hyperlipoproteinemia and Spontaneous Atherosclerosis in Mice Resulting from Gene Replacement of MouseApoewith HumanAPOE*2;” The Journal of Clinical Investigation; vol. 102; No. 1; Jul. 1998; pp. 130-135.
S.S. Kumari, et al.; “Functional Expression and Biophysical Properties of Polymorphic Variants of the Human Gap Junction Protein Connexin37;”Biochemical and Biophysical Research Communications; vol. 274; No. 1; 2000; pp. 216-224.
E. Dupont, et al.; “Altered Connexin Expression in Human Congestive Heart Failure;”J Mol Cell Cardiol; vol. 33; 2001; pp. 359-371.
S. Kumari, et al.; “Two Polymorphic Variants of Human Connexin37 Exhibit Different Biophysical Properties;”Molecular Biology of the Cell; vol. 9 (Suppl.); Nov. 1998; pp. 93a 538.
K.E. Reed, et al.; “Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein;”J. Clin. Invest.; vol. 93; No. 2; 1993; pp. 997-1004.
The European Patent Office Communication (including Supplementary Partial European Search Report) for corresponding European patent application No. 03712817(PCT/JP0303477), dated Oct. 13, 2005.
Hung-I. Yeh, et al. “Connexin37 gene polymorphism and coronary artery disease in Taiwan;”International Journal of Cardiology; vol. 81, pp. 251-255 (2001).
Werner Koch, et al. “Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction;”Atherosclerosis; vol. 159, pp. 137-144 (2001).
M. Boerma, et al. “A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development;”Journal of Internal Medicine; vol. 246, pp. 211-218 (1999).
Elvis Brscic, et al. “Acute myocardial infarction in young adults: Prognostic role of angiotensin-converting enzyme, angiotensin II type I receptor, apolipoprotein E, endothelial constitutive nitric oxide synt

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