Method of diagnosing preclinical diabetes

Details Method of diagnosing preclinical diabetes Method of diagnosing preclinical diabetes

1997-07-15

2000-03-21

Johnson, Nancy A

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 6, 435 71, 435 72, 435 724, 435965, 435975, 435 77, 435 772, 435 79, 435 792, 4353723, 436503, 436506, 436 63, 530350, 530395, 5303871, 5303913, G01N 3350, G01N 3353, G01N 33564, G01N 33567

Patent

active

060401346

ABSTRACT:
The present invention relates to a method of diagnosing preclinical insulin-dependent diabetes mellitus by determining the T cell response to a specific islet cell antigen fetal antigen 1 (FA1) or the presence of autoantibodies against FA1 in serum, a test kit for use in the method, as well as a pharmaceutical composition of FA1 and a method for use of the pharmaceutical composition for therapy of insulin-dependent diabetes mellitus.

REFERENCES:
patent: 5674692 (1997-10-01), Baekkeskov et al.
Arden, S.D. et al. Imogen38: A novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. J. Clin. Invest., 97(2): 551-561, Jan. 1997.
Aanstoot, H. et al. Identification and characterization of Glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in Type I diabetes. J. Clin. Invest., 97(12): 2772-2783, Jun. 1997.
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Kundig, et al., Proc. Natl. Acad. Sci., vol. 89, pp. 7757-7761 (Aug. 1992).
Christgau, et al., The Journal Of Biological Chemistry, vol. 266, No. 31, pp. 21257-21264 (Nov. 1991).

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