Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1996-09-30
1998-09-22
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
424 92, 424562, 424565, 435 71, 436518, 436 86, 514 12, 514 16, 514 17, 600301, G01N 3350, A61K 3804, A61K 3825
Patent
active
058110747
ABSTRACT:
A diagnostic protocol and kit for evaluating pituitary growth hormone (GH) secretory capability as a means to identify the etiology of GH deficiency in children and adults is disclosed. The inventive protocol includes measuring GH secretion, provoked by independent, sequential administration of the xenobiotic GH releasing hexapeptide (GHRP-6) or any of its peptidyl or non-peptidyl synthetic analogues (GHRX) that release GH by the same cellular mechanism as GHRP-6 followed by the naturally occurring GH releasing hormone or its analogues (GHRH) to children and adults afflicted with disorders related to GH deficiency. After evaluating the effects of independent, sequential administration of the GH secretagogues upon changes in blood GH concentrations, the effect of the co-administered GH secretagogues on blood GH concentrations in the child or adult subject is then measured.
REFERENCES:
patent: Re33699 (1991-09-01), Drengler
patent: 4517181 (1985-05-01), Ling et al.
patent: 4518586 (1985-05-01), Rivier et al.
patent: 4528190 (1985-07-01), Vale, Jr. et al.
patent: 4529595 (1985-07-01), Rivier et al.
patent: 4562175 (1985-12-01), Chang et al.
patent: 4563352 (1986-01-01), Rivier et al.
patent: 4585756 (1986-04-01), Brazeau, Jr. et al.
patent: 4595676 (1986-06-01), Spiess et al.
patent: 4605643 (1986-08-01), Bohlen et al.
patent: 4610976 (1986-09-01), Bohlen et al.
patent: 4617149 (1986-10-01), DiMarchi et al.
patent: 4622312 (1986-11-01), Felix et al.
patent: 4626523 (1986-12-01), Vale, Jr. et al.
patent: 4649131 (1987-03-01), Felix et al.
patent: 4662312 (1987-05-01), Aoki
patent: 4710382 (1987-12-01), Recker
patent: 4774319 (1988-09-01), Ono et al.
patent: 4844096 (1989-07-01), Bercu
patent: 5065747 (1991-11-01), Bercu
patent: 5246920 (1993-09-01), Bercu et al.
Cordido et al., 1993. Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity. J. Clin. Endocrinol. Metab. 76: 819-823.
Gertz et al., 1993. Growth hormone response in man to L-692,429, a novel nonpeptide mimic growth hormone-releasing peptide-6. J. Clin. Endocrinol. Metab. 77: 1393-1397.
Albini et al., "Diagnostic value of the growth hormone-releasing factor stimulation test" Clinical Pharmacol Ther., 43:696-700 (1988). factor (1-44) amide binding to rat pituitary . . . " Brain. Res., 528:291-299 (1990).
Abribat et al., "Alterations of pituitary growth hormone-releasing factor binding sites in aging rats" Endocrinology, 128:633-635 (1991).
Bercu et al., "Role of selected endogenous peptides in growth hormone releasing hexapeptide (GHRP-6) activity" Endocrinology, 130:2579-2586 (1992a).
Bercu et al., "Structural and functional responses of aged female rats to chronic co-administration of growth . . . " Abstract, Annual Mtg., San Antonio, TX, Jun. 1992, p. 182 (1992b).
Blake and Smith, "Desensitization studies using perifused rat pituitary cells show growth hormone . . . " Endocrinol., 129:11-19 (1991).
Bowers et al., "Structure-activity relationships of synthetic pentapeptide that specifically . . . " Endocrinol., 106:663-667 (1980).
Bowers et al., "Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts . . . " Endocrinol. Metab., 70:975-982 (1990).
Bowers et al., "Growth hormone (GH)-releasing activity of a synthetic hexapeptide in normal men and short statured children . . . " Endocrinol. Metab., 74:292-298 (1991).
Butenandt, "Diagnostic value of growth hormone-releasing hormone in short children" Acta Paediatr. Scand (Supp.), 349:93-99 (1989).
Ceda et al., "Diminished pituitary responsiveness to growth hormone-releasing factor in aging male rats" Endocrin., 118:2109-2114 (1986).
Chatelain et al., "Growth hormone (GH) response to single intravenous injection of synthetic GH-releasing . . . " J. Clin. Endorinol. Metab., 65:387-394 (1987).
Cheng et al., "Synergistic effects of HIS-D-TRP-ALA-TRP-D-PHE-LYS-NH" Endocrinol, 124:2971-2798 (1989).
Codd et al., "Binding of growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites" Neuropharmacology, 28:1139-1144 (1989).
DeBell et al., "Growth hormone (GH) secretion during continuous infusion of GH-releasing peptide . . ." J. Clin. Endocrinol. Metab., 72:1312-1316 (1991).
DeGennaro Colonna et al., "Reduced growth hormone releasing factor (GHRF)-like immunoreactivity . . . " Peptides, 10:705-708 (1989).
Devesa et al., "Reasons for the variability in growth hormone (GH) responses to GHRH challenges . . . " Clinical Endocrinology, 30:367-377 (1989).
Dorland's Illustrated Medical Dictionary, Twenty-fifth Edition, ed. W.B. Saunders, p. 78. "analogue".
Finkelstein et al., "Age-related change in 24-hour spontaneous secretion of growth hormone" J. Clin. Endocrinol. Metab., 35:665-670 (1972).
Ge et al., "Relationship between growth hormone-releasing hormone and somatostatin in rat . . . " J. Endocrinol., 123:53-58 (1989.
Ghigo et al., "Pyridostigmine partially restores GH responsiveness to GHRH in normal aging" Acta Endocrinol., 123:169-174 (1990).
Goth et al., "Pituitary adenylate cyclase activiating polypeptide, growth hormone (GH)-releasing peptide and GH-releasing . . . " Endrinology, 130:939-944 (1992).
Ho et al., "Effects of sex and age on 24-hour profile of growth hormone secretion in man . . . " J. Clin. Endocrinol. Metab., 64:51-57 (1987).
Iovino et al., "Repetitive growth hormone-releasing hormone administration restores the attenuated growth hormone . . . " J. Clin. Endocrinol. Metab., 69:910-913 (1989).
Jansson et al., "The dwarf little (Lit/Lit) mouse is resistant to growth hormone releasing peptide . . . " Endocrine Society Abstracts, Annual Meeting, (1986).
Kaiser et al., "Effects of recombinant human growth hormone on malnourished older individuals" J. Am. Geriatr. Soc., 39:235-240 (1991).
Lang et al., "Effects on sex and age on growth hormone response to growth hormone-releasing hormone in healthy individuals" J. Clin. Endocrinol. Metab., 65:535-540 (1987).
Lang et al., "The influence of age on human pacreatic growth hormone releasing hormone stimulated growth . . . " Horm. Metabol. Res., 20:574-578 (1988).
Marcus et al., "Effects of short term administration of recombinant human growth hormone to elderly people" J. Clin. Endocrinol. Metab., 70:519-527 (1990).
Morimoto et al., "Age-related changes in growth hormone releasing factor and somatostatin in rat hypthalamus" Neuroendocrinology, 47:459-464 (1988).
Martha et al., "A persistent pattern of varying pituitary responsivity to exogenous growth hormone . . . " J. Clin. Endocrinol. Metab., 67:449-454 (1988).
Merica et al., "Growth hormone responses to a second generation growth hormone releasing peptide . . . " Endocrine Society Abstracts, 74th Annual Mtg., San Antonio, TX, No. 477, p. 171, (1992).
Momany et al., "Design, synthesis, and biological activity of peptides which release growth hormone in vitro" Endocrinol., 108/31-39 (1981).
Momany et al., "Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides" Endocrinol., 114:1531-1535 (1984).
Ono et al., "Release of immunoreactive growth hormone-releasing factor (GRF) and somatostatin from incubated . . . " Neuroendocrinology, 43:111 (Abstract) (1986).
Parenti et al., "Different regulation of growth hormone-releasing factor-sensitive adenylate cyclase in anterior pituitary . . . " Endocrinology, 121:1649-1653 (1987).
Pavlov et al., "Responses of growth hormone (GH) and somatomedin-C to GH-releasing hormone . . . " J. Clin. Endocrinol. Metab., 62:595-600 (1986).
Pertzelan et al., "Plasma growth hormone response to synthetic GH-RH1-44 in 52 children . . . " Hormone Res., 22:24-31 (1985).
Robinson et al., "Acute growth hormone (GH) response to GH-releasing hexapeptide in humans in independent . . . " J. Clin. Endocrinol. Metab. 75:1121-1124 (1992).
Root and Oski, "Effects of human growth hormone in elderly males" J. Gerontol., 24:97-104 (1969).
Rudman et al., "Impaired growth hormone secretion in adult population" J. Clin. Invest., 67
Bercu Barry B.
Walker Richard F.
Grun James L.
Hutzell Paula K.
University of South Florida
LandOfFree
Method of diagnosing pituitary dependent growth hormone deficien does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of diagnosing pituitary dependent growth hormone deficien, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of diagnosing pituitary dependent growth hormone deficien will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1620004