Method of diagnosing pathological state of tumor cells using a d

Details Method of diagnosing pathological state of tumor cells using a d Method of diagnosing pathological state of tumor cells using a d

1997-03-27

1999-05-18

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 185, 424 189, 514 23, 514 62, 436 14, 436 95, A61K51/06;51/04

Patent

active

059049154

ABSTRACT:
A diagnostic agent for glycometabolic function comprising a glucose derivative of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents hydrogen or acyl having 2 to 8 carbon atoms, with the proviso that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is acyl and R.sup.5 represents X or --NHCOR.sup.6 X wherein X is a radioisotope of halogen and R.sup.6 is arylene or alkylene having 1 to 3 carbon atoms.

REFERENCES:
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Magata et al., "Development of a Novel Radioiodinated Glucose Derivative with Interaction to Hexokinase", Journal of Labelled Compounds and Radiopharmaceuticals, vol. 31, No. 4, 1992, pp. 317-328. F!Fluoro-D-Glucose from .sup.18 F-Labeled Acetyl Hypofluorite", The Journal of Nuclear Medicine, vol. 23, No. 10, Oct. 1982, pp. 899-903.
G. Kloster et al., "D-Glucose Derivatives Labelled with .sup.75,77 Br and .sup.123 I", Journal of Labelled Compounds and Radiopharmaceuticals, vol. 20, No. 3, 1983, pp. 391-415.
B. Connolly et al., "Affinity Labelling of the Rat Muscle Hexokinase Type II", Biochemical Society Transactions, vol. 6, No. 3, 1978, pp. 586-587.
Patent Abstracts of Japan, vol. 096, No. 002, Feb. 29, 1996.

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