Method of diagnosing ovarian, endometrial, and colon cancers wit

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 72, 435 79, 435 792, 436 63, 436813, 436518, 436512, 5303877, 5303888, 53038885, 5303897, G01N 33574, G01N 3353, C07K 1630

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054864569

ABSTRACT:
A method for detecting the presence of cancer employs monoclonal antibody OXA or OXB, antibodies which bind to the antigen bound by monoclonal antibody OXA or OXB, or fragments of the foregoing which bind to the antigen bound by monoclonal antibody OXA or OXB. The method comprises contacting a sample of a biological fluid from a subject with the antibody under conditions permitting the antibody to form a reaction product, and then detecting the presence or absence of the reaction product. The method is particularly useful for monitoring the progression of treatment in a patient previously diagnosed as having ovarian or colon cancer. The method is also useful for detecting and monitoring endometrial cancer, and for detecting colon cancer.

REFERENCES:
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Xu et al., Development of Two New Monoclonal Antibodies Reactive to a Surface Antigen Present on Human Ovarian Epithelial Cancer Cells, Cancer Research, vol. 51 (Aug. 1991), pp. 4012-4019.
Singhal et al., Profiles of Lewis.sup.x -containing Glycoproteins and Glycolipids in Sera of Patients with Adenocarcinoma, Cancer Research, vol. 50 (Mar. 1990), pp. 1375-1380.
Guadagni et al., TAG-72 (CA 72-4 Assay) as a Complementary Serum Tumor Antigen to Carcinoembryonic Antigen in Monitoring Patients with Colorectal Cancer, Cancer, vol. 72, No. 7 (Oct. 1993), pp. 2098-2106.
Herlyn et al., Increased Sensitivity in Detecting Tumor-Associated Antigens in Sera of Patients with Colorectal Carinoma, Journal of Immunological Methods, vol. 75 (1984), pp. 15-21.

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