Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-12-29
2010-10-05
Yu, Melanie (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007900, C435S007920, C436S501000, C436S518000, C436S811000
Reexamination Certificate
active
07807378
ABSTRACT:
The present invention relates to methods of diagnosing myasthenia gravis in a subject, by determining an amount of at least one autoantibody that specifically binds one or more autoantigens selected from heat-shock protein 60 (hsp60), heat-shock protein 90, alpha isoform (hsp90α), and heat-shock protein 90, beta isoform (hsp90β). The invention also provides diagnostic kits for identifying a subject having myasthenia gravis.
REFERENCES:
patent: 4033722 (1977-07-01), Lindstrom
patent: 4789640 (1988-12-01), Lindstrom
patent: 5578496 (1996-11-01), Atassi et al.
patent: 5777083 (1998-07-01), Burnie et al.
patent: 2002/0081652 (2002-06-01), Fuchs et al.
patent: 2003/0119064 (2003-06-01), Valkirs et al.
patent: 2004/0235045 (2004-11-01), Nyland et al.
patent: 2004/0241744 (2004-12-01), Kohno et al.
patent: 2005/0124076 (2005-06-01), Tseng et al.
patent: 2005/0260770 (2005-11-01), Cohen et al.
patent: 2004-4257862 (2004-09-01), None
patent: WO 03/070761 (2003-08-01), None
Pashov et al., Autoantibodies to heat shock protein 90 in the human natural antibody repertoire, International Immunology, vol. 14, No. 5, pp. 453-461.
Conroy et al., Detection of autoantibodies to the 90 kDa heat shock protein in Systemic Lupus Erythematosus and other autoimmune diseases, British Journal of Rheumatology 1994; 33: 923-926.
Kim, Diagnostic significance of antibodes to heat shock proteins, Clinica Chimica Acta 337 (2003) pp. 1-10.
Trieb et al., Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy, British Journal of Cancer (2000) 82(1), 85-87.
Kenderov et al. Lupus-specific kidney deposits of HSP90 are associated with altered IgG idiotipic interactions of anti-HSP90 autoantibodies, Clin Exp Immunol 2002; 129: 169-176.
Joachim et al., Autoantibodies in patient with glaucoma: a comparison of IgG serum antibdoes against retinal, optic nerve, and optic nerve head antigens, Graefe's Arch Clin Exp Ophthalmol (2005) 243: 817-823.
Quintana et al., Experimental autoimmune myasthenia gravis in naive non-obese diabetic (NOD/LtJ) mice: susceptibility associated with natural IgG antibodies to the acetylcholine receptor, International Immunology, vol. 15, No. 1, pp. 11-16.
Partial European Search Report for European Patent Application No. 06290012.1-2404, mailed Oct. 23, 2006 (4 pages).
R. Astarloa and J.C. Martinez Castrillo, “Humoral response to the human heat shock 60 kDa protein in myasthenia gravis,” J. Neurol. Sci. 135:182-183 (1996).
K. Yonekura et al., “Prevalence of anti-heat shock protein antibodies in cerebrospinal fluids of patients with Guillain-Barré syndrome,” J. Neuroimmunol. 156:204-209 (2004).
Cotran et al., Pathologic Basis of Disease 211-212, 1289 (W.B. Saunders Co., Philadelphia, PA; 6th ed. 1999).
Hennekens et al., Epidemiology in Medicine 331-335 (1st Ed. 1987).
Hoch et al., “Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies,”Nature Med.7(3):365-368 (2001).
Howard, “Myasthenia gravis: a summary,” available at http://www.myasthenia.org/information/summary.htm (last accessed Oct. 23, 2005).
Kirkegaard & Perry Laboratories, Inc., Technical Guide for ELISA 9-21 (2003), available at http://www.kpl.com/home.cfm# (last accessed Nov. 3, 2005).
Luo et al., “Regulation of AChR clustering by dishevelled interacting with MuSK and PAK1,”Neuron35:489-505 (2002).
Morgan et al., “The Matrix Effects on Kinetic Rate Constants of Antibody-Antigen Interactions Reflect Solvent Viscosity,”J. Immunol. Meth.217:51-60 (1998).
“Myasthenia Gravis,” available at http://www.neuroland.com
m/myas—gra.htm (last accessed Dec. 1, 2005).
Osserman, K.E. et al., “Studies in myasthenia gravis: review of a twenty-year experience in over 1200 patients,”Mt. Sinai J. Med.38(6):497-537 (1971).
Parsell et al., “The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins,”Ann Rev. Genet.27:437-496 (1993).
Ragheb et al., “Myasthenia gravis patients, but not healthy subjects, recognize epitopes that are unique to the ε-subunit of the acetylcholine receptor,”J. Neuroimmunol.159:137-145 (2005).
Richman et al., “Treatment of autoimmune myasthenia gravis,”Neurol.61:1652-1661 (2003).
Robinson et al., “Autoantigen microarrays for multiplex characterization of autoantibody responses,”Nature Med.8(3):295-301 (2002).
Roxanis et al., “Thymic myoid cells and germinal center formation in myasthenia gravis; possible roles in pathogenesis,”J. Neuroimmunol.125:185-197 (2002).
Sambrook et al., 3 Molecular Cloning: A Laboratory Manual A8.40-A8.45 and A8.52-A8.55 (Cold Spring Harbor Laboratories Press, Cold Spring Harbor, NY , 3d ed. 2001).
Scofield, “Autoantibodies as predictors of disease,”Lancet363:1544-1546 (2004).
Somnier, “Increasing incidence of late-onset anti-AChR antibody-seropositive myasthenia gravis,”Neurol.65:928-930 (2005).
Sreedhar et al., “Hsp90 isoforms: functions, expression and clinical importance,”FEBS Letters562:11-15 (2004).
Zhuang et al., “Measurement of Association Rate Constant of Antibody-Antigen Interaction in Solution Based on Enzyme-Linked Immunosorbent Assay,”J. Biosci. Bioeng.92(4):330-336 (2001).
European Search Report for European Patent Application No. 06290012.1 mailed Oct. 1, 2007.
European Search Opinion for European Patent Application No. 06290012.1 mailed Oct. 1, 2007.
D.B. Jones et al., “Sequence homologies between hsp 60 and autoantigens,” Immunology Today, vol. 14, pp. 115-118 (1993).
S.E. Conroy et al., “Incidence of anti Hsp 90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis,” Clin. Exp. Rheum. vol. 14, pp. 99-104 (1996).
S.E. Conroy et al., “Detection of antibodies to the 90kDa heat shock protein in patients with SLE and other autoimmune rheumatic diseases,” Arthritis and Rheumatism, vol. 36, p. S236 (1993).
S. Minota et al., “Autoantibodies to the heat-shock protein hsp90 in systemic Lupus Erythematosus,” Journal of Clinical Investigation, vol. 81, pp. 106-109 (1988).
Pashov et al., Autoantibodies to heat shock protein 90 in the human natural antibody repertoire, International Immunology, vol. 14, No. 5, pp. 453-461, 2002.
Conroy et al., Detection of autoantibodies to the 90 kDa heat shock protein in Systemic Lupus Erythematosus and other autoimmune diseases, British Journal of Rheumatology 1994; 33: 923-926.
Kim, Diagnostic significance of antibodes to heat shock proteins, Clinica Chimica Acta 337 (2003) pp. 1-10.
Trieb et al., Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy, British Journal of Cancer (2000) 82(1), 85-87.
Kenderov et al. Lupus-specific kidney deposits of HSP90 are associated with altered IgG idiotipic interactions of anti-HSP90 autoantibodies, Clin Exp Immunol 2002; 129: 169-176.
Joachim et al., Autoantibodies in patient with glaucoma: a comparison of IgG serum antibdoes against retinal, optic nerve, and optic nerve head antigens, Graefe's Arch Clin Exp Ophthalmol (2005) 243: 817-823.
Quintana et al., Experimental autoimmune myasthenia gravis in naive non-obese diabetic (Nod/LtJ) mice: susceptibility associated with natural IgG antibodies to the acetylcholine receptor, International Immunology, vol. 15, No. 1, pp. 11-16, 2003.
Cheng Ping-Fu
Chiu Hou-Chang
Liao Pei-Hsiu
Tsai Shih-Feng
Tseng Tzu-Ling
Counts Gary W
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Industrial Technology Research Institute (ITRI)
National Health Research Institutes (NHRI)
Shin Kong Wu Ho-Su Memorial Hospital
LandOfFree
Method of diagnosing myasthenia gravis and kits therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of diagnosing myasthenia gravis and kits therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of diagnosing myasthenia gravis and kits therefor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4177306