Method of diagnosing myasthenia gravis and kits therefor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007900, C435S007920, C436S501000, C436S518000, C436S811000

Reexamination Certificate

active

07807378

ABSTRACT:
The present invention relates to methods of diagnosing myasthenia gravis in a subject, by determining an amount of at least one autoantibody that specifically binds one or more autoantigens selected from heat-shock protein 60 (hsp60), heat-shock protein 90, alpha isoform (hsp90α), and heat-shock protein 90, beta isoform (hsp90β). The invention also provides diagnostic kits for identifying a subject having myasthenia gravis.

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Quintana et al., Experimental autoimmune myasthenia gravis in naive non-obese diabetic (Nod/LtJ) mice: susceptibility associated with natural IgG antibodies to the acetylcholine receptor, International Immunology, vol. 15, No. 1, pp. 11-16, 2003.

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