Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1993-05-14
1995-10-31
Czaja, Donald E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
436 63, 436501, 436504, 436811, C12Q 102
Patent
active
054628598
ABSTRACT:
An isolated associated complex of bile acid salts and brush border membrane protein and a method of diagnosing irregularities in bile salt absorption via brush border membrane proteins is presented. In addition a method for detecting specific binding of bile salts to intestinal brush border membrane protein is disclosed.
REFERENCES:
patent: 4760135 (1988-07-01), Diedrich et al.
patent: 4769334 (1988-09-01), Fleming
patent: 4806532 (1989-02-01), Dousa
patent: 4863852 (1989-09-01), Wilkins et al.
patent: 4908321 (1990-03-01), Varma
patent: 5120641 (1992-06-01), Hashimoto et al.
Brunner, J. et al. "Single Bilayer Lipid-Protein Vesicles Formed from Phosphatidylcholine and Small Intestinal Sucrase-Isomaltase", J. Biol. Chem., vol. 235, No. 20, (1978) pp. 7538-7546.
Kessler, M. et al. "A Modified Procedure for the Rapid Preparation of Efficiently Transporting Vesicles from Small Intestinal Brush Border Membranes: Their Use in Investigating Some Properties of .sub.D -Glucose and Choline Transport Systems", Biochimica et Biophysica Acta, vol. 506, (1978) pp. 136-154.
Hauser, H. et al. "Rabbit Small Intestinal Brush Border Membrane Preparation and Lipid Composition", Biochimica et Biophysica Acta, vol. 602, (1980) pp. 567-577.
Hauser, H. et al. "Orientation and Motion of Spin-Labels in Rabbit Small Intestinal Brush Border Vesicle Membranes", Biochemistry, vol. 21, (1982) pp. 5621-5628.
Child, P. et al. "Uptake of 7-dehydro Derivatives of Cholesterol, Campesterol, and.beta.-sitosterol by Rat Erythrocytes, Jejunal Villus Cells, and Brush Border Membranes", J. Lipid Res., vol. 24, (1983) pp. 552-565.
Ikeda, I. et al. "Some Aspects of Mechanism of Inhibition of Cholesterol Adsorption by.beta.-Sitosterol ", Biochemica et Biophysica Acta, vol. 732, (1983) pp. 651-658.
Proulz, P. et al. "The Effect of Phosphoglycerides on the Incorporation of Cholesterol into Isolated Brush-Border Membranes from Rabbit Small Intestine", Biochimica et Biophysica Acta, vol. 775, (1984) pp. 341-346.
Lasic, D. D. et al. "The Potential of Electron Spin Resonance Spin-Labeling in Determining Micelle Shapes", J. Physical Chem., vol. 89, No. 12, (1985) pp. 2648-2651.
Proulx, P. et al. "Studies on the Uptake of Fatty Acids by Brush Border Membranes of the Rabbit Intestine", Can. J. Biochem. Cell Biol., vol.63, (1985) pp. 249-255.
Vallet--Strouve, C. et al. "Effect of Micellar Lipids on Rabbit Intestinal Brush-Border Membrane Phospholipid Bilayer Integrity Studied by.sup.31 P NMR", J. Membrane Biol., vol. 84, (1985) pp. 73-79.
Mutsch, B. et al. "Interaction of Intestinal Brush Border Membrane Vesicles with Small Unilamellar Phospholipid Vesicles. Exchange of Lipids between Membranes is Mediated by Collisional Contact", Biochemistry, vol. 25, (1986) pp. 2134-2140.
Proulx, P. et al. "Factors Influencing the Uptake of Cholesterol by Isolated Brush Border Membranes from Rabbit Small Intestine", Exp. Biol., vol. 45, (1986) pp. 335-343.
Tellier, C. et al. "Interactions between Biliary Lipid Micelles and Intestinal Brush Border Membranes Investigated by.sup.1 H and.sup.31 P Nuclear Magnetic Resonance", Eur. Biophys. J., vol. 15 (1987) pp. 177-184.
Ikeda, I. et al. "Inhibition of Cholesterol Absorption in Rats by Plant Sterols", J. Lipid Res., vol. 29, (1988) pp. 1573-1582.
Ikeda, I. et al. "Discrimination between Cholesterol and Sitosterol for Absorption in Rats", J. Lipid Res., vol. 29, (1988) pp. 1583-1591.
Chijiiwa, K. et al. "Bile Salt Micelle Can Sustain More Cholesterol in the Intermicellar Acqueous Phase than the Maximal Acqueous Solubility", Arch. Biochem. Biophys., vol. 270, No. 2, (1989) pp. 472-477.
Thurnhofer, H. et al. "Uptake of Cholesterol by Small Intestinal Brush Border Membrane Is Protein-Mediated", Biochemistry, vol. 29, (1990) pp. 2142-2148.
Thurnhofer, H. et al. "The Uptake of Phosphatidylcholine by Small Intestinal Brush Border Membrane is Protein-Mediated", Biochimica et Biophysica Acta, vol. 1024, (1990) pp. 249-262.
Lipka, G. et al. "Lipid Asymmetry in Rabbit Small Intestinal Brush Border Membrane as Probed by an Intrinsic Phospholipid Exchange Protein", Biochemistry, vol. 30, (1991) pp. 11828-11836.
Thurnhofer, H. et al. "Cholesterol-Transfer Protein Located in the Intestinal Brush-Border Membrane. Partial Purification and Characterization", Biochimica et Biophysica Acta, vol. 1064, (1991) pp. 275-286.
Thurnhofer, H. et al. "Membrane Proteins Exposed on the External Side of the Intestinal Brush-Border Membrane Have Fusogenic Properties", Eur. J. Biochem., vol. 201, (1991) pp. 273-282.
Czaja Donald E.
Tran Lien
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