Method of diagnosing growth hormone disorders employing somatost

Details Method of diagnosing growth hormone disorders employing somatost Method of diagnosing growth hormone disorders employing somatost

1989-11-14

1991-11-19

Rosenbaum, C. Fred

Surgery

Truss

Pad

128632, 424 9, 604 49, A61B 500

Patent

active

050657488

ABSTRACT:
A patient thought to have a hypoactive pituitary or a pituitary that secretes a normal amount of growth hormone in abnormal patterns is given an intravenous bolus of somatostatin at the beginning of a test period. The bolus is followed by an infusion of somatostatin for a two hour period. The infusion is terminated and an intravenous bolus of growth hormone releasing hormone is then administered. The test is performed during the patient's waking hours and a blood sample is taken every twenty minutes to monitor the amount of growth hormone in the patient's bloodstream. The patient is diagnosed based upon the amount of growth hormone released during the treatment, and the rebound rate of growth hormone secretion after suppression. The somatostatin part of the procedure also has utility in connection with the diagnosis of differing types of gigantism and acromegaly.

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Barkan et al., "Treatment of Acromegaly with Long-Acting Somatostatin Analog SMS 201-995*", Journal of Clinical Endocrinology and Metabolism, vol, 66, No. 1, pp. 16-23, 1988.
Shi, Y. et al., "Clinical and Biochemical Effects of Incremental Doses of the Long-Acting Somatostatin Analog SMS 201-995 in Ten Acromegalic Patients", Clinical Endocrinology, 32(6), 1990, pp. 695-706.

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