Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-03-27
1987-11-03
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436501, 436548, 436811, 436815, 935110, G01N 3353, G01N 33577
Patent
active
047043563
ABSTRACT:
It is found that abnormal levels of keratan sulfate in the peripheral blood are indicative of abnormalities of cartilage or cartilage-like tissues. Specifically, elevated levels of keratan sulfate in the peripheral blood plasma or serum are indicative of osteoarthritis and either substantially complete absence of or very elevated levels of keratan sulfate in the peripheral blood are indicative of muscular dystrophy and related disorders. The level of keratan sulfate in the peripheral blood is determined by an immunoassay using a monoclonal antibody. Preferably the immunoassay employs a colorimetric reporter system.
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A. L. Fluharty, The Journal of Investigative Dermatology, 79: 38s-44s (1982).
E. J-M. Thonar et al., The Journal of Biochemistry, 257: 14173-14180 (1982).
Nucker Christine M.
Rush-Presbyterian-St. Luke's Medical Center
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