Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2001-08-24
2010-02-16
Kapushoc, Stephen (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100
Reexamination Certificate
active
07662552
ABSTRACT:
The method of diagnosing lesions of crystalline lens such as cataract is disclosed. It comprises detecting variation of crygs gene, transcript and/or protein of individuals compared with normalty. The individual suffers from cataract more possible than normalty when occurring the variation. The present invention also discloses the method and pharmaceutical composition of treating lesions of crystalline lens such as cataract.
REFERENCES:
patent: WO 9830677 (1998-07-01), None
Sinha D, Esumi N, Jaworski C, Kozak CA, Pierce E, Wistow G.., Cloning and mapping the mouse Crygs gene and non-lens expression of [gamma]S-crystallin.Mol Vis. Apr. 30, 1998;4: p. 8.
Mummidi (2000) Journal of Bilogical Chemistry, vol. 275, No. 25, pp. 18946-18961.
Bork (1993) Protein Science vol. 2, pp. 31-40.
Juppner (1995) Bone, vol. 17, No. 2, pp. 39S-42S.
Sun H, Ma Z, Li Y, Liu B, Li Z, Ding X, Gao Y, Ma W, Tang X, Li X, Shen Y. Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans.J Med Genet. Sep. 2005;42(9):706-10.
dbSNP for rs4165301, available online from www.ncbi.nlm.nih.gov/SNP. pp. 1-4.
GeneCard output for CRYGS, available from www.genecards.org, pp. 1-11.
Hegele RA ‘SNP judgments and freedom of association.’ Arterioscler Thromb Vasc Biol. Jul. 1, 2002;22(7):1058-61.
Bu Lei
Hu Liandian
Jin Meilei
Jin Yiping
Kong Xiangyin
Kapushoc Stephen
Merchant & Gould P.C.
Shanghai Institutes of Biological Science, Chinese Academy of Sc
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