Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-11-28
2000-02-22
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
424 137, 435 71, 435 721, C07K 100, G01N 3353, G01N 33567, A61K 5100
Patent
active
06028174&
ABSTRACT:
The present invention provides a recombinant toxin and monoclonal antibody which specifically binds to glial-derived or meningioma-derived tumor cells. Also provided are various methods of screening for malignant gliomas and meningiomas. Further provided are methods of treating malignant gliomas, including glioblastoma multiforme and astrocytomas.
REFERENCES:
Kunwar et al, J Neurosurg, 79, 569-576, 1993.
Ullrich et al, NeuroReport, 7, 1020-1024, 1996.
Somogyi et al, J Neuroscience, 9, 2197-2209, 1989.
Sontheimer Harald W.
Ullrich Nicole
Adler Benjamin Aaron
Hutzell Paula K.
Sun-Hoffman Lin
UAB Research Foundation
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