Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2001-08-30
2008-07-08
Sitton, Jehanne (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200
Reexamination Certificate
active
07396644
ABSTRACT:
The invention has disclosed a method for diagnosis of dentinogenesis imperfecta type II (DGI-II) and/or dentinogenesis imperfecta type II with deafness (DGI-II with deafness). Said method comprises the steps of detecting the DSPP gene, transcript and/or protein in said subject and comparing it with the normal DSPP gene, transcript and/or protein to determine whether there is any variation, wherein said variation indicates that the possibility of suffering DGI-II and/or DGI-II with deafness in said subject is higher than the normal population. The present invention also discloses the method and pharmaceutical composition for treating DGI-II and/or DGI-II with deafness.
REFERENCES:
Gu K, Chang S, Ritchie HH, Clarkson BH, Rutherford RB. Molecular cloning of a human dentin sialophosphoprotein gene.Eur J Oral Sci. Feb. 2000;108(1):35-42.
Hacker et al (1997) Gut vol. 40, p. 623-627.
Thisted et al (1998) What is a P-value?, available online at www.stat.uchigao.edu/˜thisted.
Deng et al (2001) Annals of Human Genetics, vol. 65, No. 3, pp. 313-329.
Lucentini (2004) The Scientist, vol. 18, issue 24, p. 20.
Zhang et al (2001) Nature Genetics, vol. 27 pp. 151-152.
GeneCard for protein coding DSPP, avaialbe from www.genecards.org, pp. 1-9.
MacDougall M., Eur J Oral Sci Jan. 1998; 106 Suppl 1:227-33, “Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci.”
Mary MacDougall et al. J Biol Chem 1997; 272(2):835-42, “Dentin Phosphoprotein and Dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4.”
Hu Landian
Kong Xiangyin
Xiao Shangxi
Yu Chuan
Zhao Guoping
Kapushoc Stephen
Merchant & Gould P.C.
Shanghai Institutes of Biological Science, Chinese Academy of Sc
Sitton Jehanne
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