Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1990-06-01
1997-01-21
Naff, David M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
424 91, 435 19, C12Q 146, C12Q 144
Patent
active
055958834
ABSTRACT:
A method is provided for diagnosing of senile dementia of the Alzheimer type (Alzheimer's disease) by measuring acetylcholinesterase (AChE) activity in ocular fluids and determining if such AChE activity is elevated over that found in ocular fluids of patients who do not have Alzheimer's disease. A level of AChE activity in the ocular fluid of a patient less than 30% higher than the level of AChE activity in the ocular fluids of a significant number of age-matched controls signifies the absence of Alzheimer's disease. A level of AChE activity in the ocular fluid of a patient at least about 35% higher than the level of AChE activity in the ocular fluids of a significant number of age-matched controls signifies the presence of Alzheimer's disease.
REFERENCES:
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Atack, J. R. et al., "Cerebrospinal Fluid Cholinesterases in Aging and in Dementia of the Alzheimher type," Biological Abstracts 85:105454, 1988.
Yamamoto, Y. et al., "Plasma and Serum G4 isoenzyme of Acetylcholinesterase in Patients with Alzheimer-type Dementia and Vascular Dementa," Biological Abstracts, 90:92062, 1990.
Mattio, T. G. et al (1984) "Effects of DFP on iridic metabolism and release of acetylcholine and on pupillary function in the rat," Neuropharmacology, 23, 1207-1214.
Hutchins, H. B. and Hollyfield, M. G. (1987) "Acetylcholinesterase in the human retina," Brain Res. 400, 300-311.
De Roeth, A. (1950) "Cholinesterase activity in ocular tissues and fluids," Arch. Ophthalmol. 43, 1004-1025.
Appleyard, M. E., et al (1987) Brain 110, 1309-1322.
Appleyard Margaret E.
McDonald Brendan
E. R. Squibb & Sons Inc.
Naff David M.
Rodney Burton
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