Method of determining the viability of tissue in an organism

Details Method of determining the viability of tissue in an organism Method of determining the viability of tissue in an organism

1985-06-06

1989-04-25

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, A61K 4902, A61K 4900

Patent

active

048246603

ABSTRACT:
A method of determining the viability of tissue in a region of an organism comprises the steps of introducing an ATP repleting agent into the region and monitoring the region to determine its effect on T1-201 distribution in the region. The capability of viable tissue to synthesize ATP and increase its ATP stores provides an indication of the viability of the tissue in the region. In a preferred embodiment of the method, ribose, which is a high energy phosphate precursor and an ATP repleting agent, is introduced into heart tissue that is being monitored by T1-201 scintigraphy. The ribose increases the rate and extent of T1-201 distribution in the heart tissue, thereby allowing the determination of viable "stunned" heart tissue. That viable tissue is distinguishable from nonviable tissue is attributed to the capability of the former to synthesize ATP and increase its ATP stores in response to the administration of the ATP repleting agent. Such manipulation of ATP stores in a region of tissue effects a detectable change in T1-201 distribution in that region. The method permits, therefore, the rapid determination of viable heart tissue.R

REFERENCES:
patent: 4364922 (1982-12-01), Berne et al.
Knapp et al., J. Nuclear Medicine, 25(9), pp. 989-997 (1984).
Melin, Jacques A. et al., "Differences in Thallium-201 Uptake in Reperfused and Nonreperfused Myocardial Infarction," Circulation Research, vol. 53, No. 3, Sep. 1983, pp. 414-419.
Braunwald, Eugene et al., "The Stunned Myocardium: Prolonged Post-Ischemic Ventricular Dysfunction," Circulation, vol. 66, No. 2, Dec. 1982, pp. 1146-1149.
Pohost, Gerald M. et al., "Thallium Redistribution: Mechanisms and Clinical Utility," Seminars in Nuclear Medicine, vol. X, No. 1, Jan. 1980, pp. 70-93.
Liu, Peter et al., "Normalization of Persistent Defects on Thallium Scans after Myocardial Revascularization: Scar or Ischemia?", Journal of American College of Cardiology, vol. 3, No. 2, Feb. 1984, p. 607.
Zimmer, H.-G., "Effects of Inosine on Cardiac Adenine Nucleotide Metabolism in Rats," Advances in Myocardiology, vol. 6, 1985, pp. 173-183.
Angello, Debra A. et al., "The Effect of Eating on Thallium-201 Myocardial Redistribution Post Ischemia," Report Under Medical Research Foundation and NRSA Grant, F32-HC07135-01 From the National Institutes of Health, Bethesda, Md.
Angello, Debra A. et al., "Effect of Ribose on Postischemic Thallium-201 Kinetics," Report Under NRSA grant F32-HL07135-01 from the National Institutes of Health, Bethesda, Md., and the American Heart Association, Oregon Affiliate.
Strauss, H. William et al., "Thalium-201 for Myocardial Imaging-Relation of Thallium-201 to Regional Myocardial Perfusion," Circulation, vol. 51, Apr. 1975, pp. 641-645.
Carlin, Ronald D. and Jan, Kung-Ming, "Mechanism of Thallium Extraction in Pump Perfused Canine Hearts," The Journal of Nuclear Medicine, vol. 26, No. 2, Feb. 1985, pp. 165-169.
Gehring, P. J. and Hammond, P. B., "The Interrelationship Between Thallium and Potassium in Animals," The Journal of Pharmacology and Experimental Therapeutics, vol. 155, No. 1, Jan. 1967, pp. 187-201.
Weiss, Edward S. et al., "Evaluation of Myocardial Metabolism and Perfusion with Positron-Emitting Radionuclides," Progress in Cardiovascular Diseases, vol. XX, No. 3, Nov./Dec. 1977, pp. 191-206.
Bergmann, Steven R. et al. "The Dependence of Accumulation of NH.sub.3 by Myocardium on Metabolic Factors and Its Implications for Quantitative Assessment of Perfusion," Circulation, vol. 61, No. 1, Jan. 1980, pp. 34-43.
L'Abbate, A. et al., "Myocardial Kinetics of Thallium and Potassium in Man," Circulation, vol. 60, No. 4, Oct. 1979, pp. 776-785.
Mullani, Nizar A. et al., "Myocardial Perfusion with Rubidium-82.1, Measurement of Extraction Fraction and Flow with External Detectors," The Journal of Nuclear Medicine, vol. 24, Oct. 1983, pp. 898-906.
Selwyn, Andrew P. et al., "Relation Between Regional Myocardial Uptake of Rubidium-82 and Perfusion: Absolute Reduction of Cation Uptake in Ischemia," The American Journal of Cardiology, vol. 50, Jul. 1982, pp. 112-121.
Wilson, Richard A. et al., "Rubidium-82 Myocardial Uptake and Extraction after Transient Ischemia: PET Characteristics," Journal of Computer Assisted Tomography, vol. 11, Jan./Feb. 1987, pp. 60-66.
Kline, Robert C. et al., "Myocardial Imaging in Man with 1-123 Meta-Iodobenzylguanidine," The Journal of Nuclear Medicine, vol. 22, No. 2, Feb. 1981, pp. 129-132.
Holman, B. Leonard, and Sia, S. T. Benjamin, "Cardiac Scintigraphy with Technetrium Isonitriles," Cardio Imaging, May 1987, pp. 34-38, 77.
Deutsch, Edward et al., "Cationic Tc-99m Complexes as Potential Myocardial Imaging Agents," The Journal of Nuclear Medicine, vol. 22, No. 10, Oct. 1981, pp. 897-907.
Holman, B. Leonard et al., "A New TC-99m Labeled Myocardial Imaging Agent, Hexakis (t-Butylisonitrile)-Technetrium (1) [Tc-99m TB1]: Initial Experience in the Human," The Journal of Nuclear Medicine, vol. 25, Dec. 1984, pp. 1350-1355.
Zimmer, H.-G. et al., "Ribose Intervention in the Cardiac Pentose Phosphate Pathway is not Species-Specific," Science, vol. 223, Feb. 1984, pp. 712-714.
Zimmer, H.-G. et al., "De Novo Synthesis of Myocardial Adenine Nucleotides in the Rat," Circulation Research, vol. XXXII, May 1973, pp. 635-642.
Lazer, Harold L., "Myocardial Energy Replenishment and Reversal of Ischemic Damage by Substrate Enhancement of Secondary Blood Cardioplegia with Amino Acids during Reperfusion," The Journal of Thoracic and Cardiovascular Surgery, vol. 80, No. 3, Sep. 1980, pp. 350-359.
Harmsen, Eef et al., "Enhanced ATP and GTP Synthesis from Hypooxanthine or Inosine after Myocardial Ischemia," pp. H37-H43.
Marshall, Robert C. et al., "Identification and Differentiation of Resting Myocardial Ischemia and Infarction in Man with Positron Computed Tomography, .sup.18 F-labeled Fluorodeoxyglucose and N-13 Ammonia," Circulation, vol. 67, No. 4, Apr. 1983, pp. 766-778.
Gibson, Robert S., et al., "Prospective Assessment of Regional Myocardial Perfusion Before and After Coronary Revascularization Surgery by Quantitative Thallium-201 Scintigraphy," Journal of American College of Cardiology, vol. 1, No. 3, Mar. 1983, pp. 804-815.
Wynne, Joshua and Holman, Leonard, "Acute Myocardial Infarct Scintigraphy with Infarct-Avid Radiotracers," The Medical Clinics of North America, vol. 64, No. 1, Jan. 1980, pp. 119-144.
Ellis, Stephen G. et al., "Response of Reperfusion-salvages, Stunned Myocardium to Inotropic Stimulation," American Heart Journal, vol. 107, No. 1, Jan. 1984, pp. 13-19.
Maurer, Gerald and Nanda, Navin C., "Two Dimensional Echocardiographic Evaluation of Exercise- Induced Left and Right Ventricular Asynergy: Correlation with Thallium Scanning," The American Journal of Cardiology, vol. 48, Oct. 1981, pp. 720-727.
Bodenheimer, Monty M. et al., "Relationship Between Regional Myocardial Perfusion and the Presence, severity and Reversibility of Asynergy in Patients with Coronary Heart Disease," Circulation, vol. 58, No. 5, Nov. 1978, pp. 789-795.
Popio, Kenneth A. et al., "Post-Extrasystolic Potentiation as a Predictor of Potential Myocardial Viability: Preoperative Analyses Compared with Studies after Coronary Bypass Surgery," The American Journal of Cardiology, vol. 39, Jun. 1977, pp. 944-953.
Zimmer, H.-G. et al., "Stimulation of Myocardial Adenine Nucleotide Biosynthesis by Pentoses and Pentitols," European Journal of Physiology, vol. 376, 1978, pp. 223-227.
Zimmer, H.-G., "Restitution of Myocardial Adenine Nucleotides: Acceleration by Administration of Ribose," Journal de Physiologie, vol. 76, No. 7, Jul. 1980, pp. 769-775.
Pasque, Michael K. et al., "Ribose-Enhanced Myocardial Recovery Following Ischemia in the Isolated Working Rat Heart," The Journal of Thoracid and Cardiovascular Surgery, vol. 83, No. 3, Mar. 1982, pp. 380-398.
Siess, M. et al., "Cardiac Synthesis and Degradation of Pyridine Nucleotides and the Level of Energy-Rich Phosphates Influenced by Various Precursors," Advances in Myocardiology, vol. 4, 1983, pp. 287-308.
Wilson, Richard A. et al., "Effect of Glucose-Insulin-Potassium Infusion on

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