Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-06-14
2011-06-14
Johannsen, Diana B (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C536S023500, C530S350000
Reexamination Certificate
active
07960107
ABSTRACT:
The present application identifies the involvement of the HIFβ-homologous Arntl2 gene in the control of type 1 (insulin-dependent) diabetes. Accordingly, the present invention provides a method of determining the susceptibility of a subject to developing insulin-dependent diabetes based on the expressing level of the Arntl2 gene. The present invention also provides a method for identifying compounds effective for treating or preventing insulin-dependent diabetes in a subject in need thereof and a method of treating or preventing insulin-dependent diabetes by administering an effective amount of compound identified by the identification method. The present invention also provides a method of enhancing protection against insulitis progression or autoimmune diabetes development in a subject in need thereof comprising, enhancing expression of the Arntl2 gene or modulating the expression of target genes thereof.
REFERENCES:
patent: 2009/0181915 (2009-07-01), Avner et al.
patent: WO 2006019824 (2006-02-01), None
Gunton, J.E. et al. Cell 122:337-349 (Aug. 2005).
Rudic, R.D. et al. Methods in Enzymology 393:524-539 (Apr. 2005).
Hung, M-S et al. Human Molecular Genetics 15(18):2732-2742 (Aug. 2006).
Avner Philip
Hung Ming-Shiu
Rogner Ute Christine
Institut Pasteur
Johannsen Diana B
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
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