Method of determining susceptibility to bipolar disorders

Details Method of determining susceptibility to bipolar disorders Method of determining susceptibility to bipolar disorders

2006-02-14

2006-02-14

Martinell, James (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200

Reexamination Certificate

active

06998235

ABSTRACT:
Methods and kits for determining susceptibility of a patient to bipolar disorders are described. The method comprises the steps of: (a) obtaining a sample from a patient; and (b) testing the sample for the presence of a polymorphism selected from (i) a 2 repeat allele in the variable number of tandem repeat (VNTR) region of the DRD4 gene and (ii) a 4 repeat allele in the VNTR region of the DRD4 gene, wherein the presence of the 2 repeat allele indicates that the patient is less susceptible to a bipolar disorder and the presence of the 4 repeat allele indicates that the patient is more susceptible to a bipolar disorder.

REFERENCES:
patent: 6132724 (2000-10-01), Blum et al.
patent: 6203998 (2001-03-01), Civelli et al.
Bocchetta, A. et al., “Family-Based Association Study Between Biopolar disorder and DRD2, DRD4, DAT and SERT in Sardinia”, American Journal of Medical Genetics, 1999, pp. 522-526, vol. 88.
Furlong, R. A. et al., “Analysis and Metaanalysis of Two Polymorphisms Within the Tyrosine Hydroxylase Gene in Bipolar and Unipolar Affective Disorders”, American Journal of Medical Genetics, 1999, pp. 88-94, vol. 88.
Jovanovic, V. et al., “Comparative pharmacological and functional analysis of the human dopamine D4 2and D4 10receptor variants”, Pharmacogentics, 1999. pp. 561-568, vol. 9.
Lichter, J. B. et al., “A hypervariable segment in the human dopamine receptor D4(DRD-4) gene”, Human Molecular Genetics, 1993, pp. 767-773, vol. 2, No. 6.
Lim, L. C. C. et al., “No Evidence of Association Between Dopamine D4 Receptor Variants and Bipolar Affective Disorder”, American Journal of Medical Genetics, 1994, pp. 259-263, vol. 54.
Muglia, P. et al., “Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4”, Molecular Psychiatry, 2002, pp. 1-7.
Van Tol, H. H. M. et al., “Multiple dopamine D4 receptor variants in the human population”, Nature, 1992, pp. 149-152, vol. 358.
Van Tol, H. H. M. et al., “Cloning of the gene for human dopamine D4receptor with high affinity for the antipsychotic clozapine”. Nature, 1991, pp. 610-614, vol. 350, No. 6319.
Asghari, V. et al., “Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants”, Journal of Neurochemistry, 1995, pp. 1157-1165, vol. 65, No. 3.
Ding, Y. C. et al., “Evidence of positive selection acting at the human dopamine receptor D4 gene locus”. PNAS, 2002, pp. 309-314, vol. 99, No. 1.
Chang, F. M. et al., “The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus”, Hum Genet, 1996, pp. 91-101, vol. 98.
De Bruyn. A. et al., “Nonlinkage of Bipolar Illness to Tyrosine Hydroxylase, Tyrosinase. and D2and D4Dopamine Receptor Genes on Chromosome 11”. American Journal of Psychiatry, 1994, pp. 102-106, vol. 151, No. 1.
Serretti, A. et al., “Genetic variants of dopamine receptor D4 and psychopathology”, Schizophrenia, 1999, pp. 609-618, vol. 23, vol. 3.
Serretti. A. et al., “Dopamine receptor D4 gene is not associated with major psychoses”, Am. J. Med. Genet., 1999, pp. 486-491, vol. 88, No. 5.
Serretti, A. et al., “DRD4 exon 3 variants associated with delusional symptomatology in major psychoses: a study on 2,011 affected subjects”. Am. J. Med. Genet. 2001, pp. 283-290, vol. 8, No. 105.

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