Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Reexamination Certificate
2007-01-09
2007-01-09
Lankford, Jr., Leon B. (Department: 1651)
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
C435S325000, C530S827000, C530S850000, C530S852000
Reexamination Certificate
active
10898041
ABSTRACT:
This invention describes unique patterns of distribution of ganglioside GM1in non-capacitated sperm and demonstrates that the pattern of distribution of GM1undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm to respond to capacitation and/or acrosomal exocytosis stimuli. The method comprises determination of distribution pattern for GM1. The method can be used for both diagnostic and predictive purposes when assessing male reproductive fitness, and can also be used to assess the effects on sperm of cryoprotective agents and protocols, and contraceptive agents.
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Kopf Gregory S.
Travis Alexander J.
Cornell Research Foundation Inc.
Ford Allison M.
Hodgson & Russ LLP
Lankford , Jr. Leon B.
Trustees of the University of Pennsylvania
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