Method of determining pregnanediol in female urine and test devi

Details Method of determining pregnanediol in female urine and test devi Method of determining pregnanediol in female urine and test devi

1981-09-23

1984-05-22

Nucker, Christine M.

Chemistry: analytical and immunological testing

Immunochemical pregnancy determination

436527, 436800, 436804, 436814, 435 7, 422 56, G01N 3352, G01N 3354, G01N 3358, G01N 2100

Patent

active

044502397

ABSTRACT:
A method is provided for determining the concentration of pregnanediol glucuronide (PG) in a woman's urine which is characterized by utilization of the reagent 20.alpha.-hydroxy-4-pregnen-3-one (20-.alpha. reagent) in a form in which it reacts with antibodies binding to PG. The method is adaptable to a visual color indication test which can be performed by the woman herself as well as by laboratory analysis. The method can be used to define the period in which conception can occur, to define a post-ovulation safe period in which conception is prevented, and as an early pregnancy indicator.

REFERENCES:
patent: 4123510 (1978-10-01), Banik et al.
Chaudhri et al., J. Ster. Biochem., 13 (1980) 691-696.
DiPietro, Chem. Abstracts, 85 (1976) Abstract #89683a.
Manita et al., Chem. Abstracts, 88 (1978) Abstract #132867q.
Chatterton et al., Chem. Abstracts 96 (1982) Abstract #211087d.
Chaudhri et al., J. Ster. Biochem. 16 (1982) 87-92.
Judge, et al., Steroids 31: 175-187 (1978).
Samarajeewa et al., J. Steroid Biochem. 11: 1165-1171.
Collins et al., Acta Endocrinologica 90: 336-348 (1979).

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