Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1994-01-19
1996-06-25
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 4, 4352871, 4352879, 436 34, 436 43, 436 50, 436 51, 436 63, 436174, 436179, 436180, 436811, C12Q 102, C12Q 100, C12M 134, G01N 3349
Patent
active
055299075
ABSTRACT:
The present invention relates to a method of determining the metabolic state of neutrophils present in the body of a patient. In particular, the present invention involves the measurement of the rates of in vitro glycolysis in blood samples taken from individuals as a function of the number of selected cells present in the blood sample, including neutrophils and red blood cells. The physiologic information provided by the present method, which, for example, indicates whether an individual's neutrophils are in a quiescent, primed or activated state, allows the medical practitioner to attain a better understanding of the patient's condition and, consequently, assists in the diagnosis and formulation of proper treatment.
REFERENCES:
Bone "Inhibitors of Complement & Neutophils: A Critical Evaluation of Their Role in The Treatment of Sepsis" Crit. Care Med. 20(6) 891-898 1992.
Bone et al. "Definitions for Sepsis & Organ Failure & Guidelines for the Use of Innovative Therapier Sepsis" Chest 101(6) 1644-1655 1992.
Nuijens, et al. "Plasma elastase, .varies..sub.1 -antitypsin, & Lactojerrin In Sepsis: Evidence for Neutrophils as Medlators In fatal Sepsis" J Lab Clin Med 199(2) 159-168 1992.
Baroso-Aranda et al. "Transformation of Neutrophils As Indicator of Irreversibility in Hemorrhagic Shock" Am. J. Physiol. 257 H846-H852 1989.
Rothe et al. "Flow Cytometric Parametrs of Neutrophil Function as Early Indicators of Sepsis or Trauma Related Pulomonery or Cardiovascular Organ Failure" J Lab Clin Med 115(1)52-61 1990.
Kalb Thomas H.
Nierman David M.
Degen Nancy J.
Fleisher Mindy
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