Method of determining odorant compounds and antagonists of odora

Details Method of determining odorant compounds and antagonists of odora Method of determining odorant compounds and antagonists of odora

1993-06-21

1995-01-10

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

4352401, 4352402, 43524021, 435975, C12Q 102, C12N 500

Patent

active

053806514

ABSTRACT:
Primary cultures of purified olfactory neurons can be stimulated with physiological levels of odorants. The neurons of the cultures express markers characteristic of mature olfactory neurons in vivo, such as vimentin, olfactory marker protein and neuron-specific enolase. The cultures are useful for screening for odorants and antagonists, as well as for biochemical and physiological studies of olfactory transduction. The olfactory neurons may comprise at least about 85% of cells in the culture. The olfactory neurons demonstrate responsiveness in culture to IBMP, citraliva, and isovaleric acid.

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