Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1993-06-21
1995-01-10
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
4352401, 4352402, 43524021, 435975, C12Q 102, C12N 500
Patent
active
053806514
ABSTRACT:
Primary cultures of purified olfactory neurons can be stimulated with physiological levels of odorants. The neurons of the cultures express markers characteristic of mature olfactory neurons in vivo, such as vimentin, olfactory marker protein and neuron-specific enolase. The cultures are useful for screening for odorants and antagonists, as well as for biochemical and physiological studies of olfactory transduction. The olfactory neurons may comprise at least about 85% of cells in the culture. The olfactory neurons demonstrate responsiveness in culture to IBMP, citraliva, and isovaleric acid.
REFERENCES:
patent: H201 (1987-01-01), Yager
patent: 5217893 (1993-06-01), Ronnett et al.
patent: 5318907 (1994-06-01), Ronnett et al.
Hirsch, J. D. and Margolis, F. L. (1979), Brain Res., 161:277-291.
Kleene, S. J. and Gesteland, R. C. (1981), Brain Res., 229-536-540.
Noble, et al., (1984) Neurosci. Letts., 45:193-198.
Gonzales, et al., (1985), J. Neurosci. Methods, 14:77-90.
Ronnett, Hester and Snyder (1989), Neuroscience Abstracts, 12:749.
Coon, et al., (1989), Proc. Natl. Acad. Sci. USA, 86:1703-1707.
Calof, A. L. and Chikaraishi, D. M. (1989), Neuron, 3:115-127.
Pixley, S. K. and Pun, R. Y. K. (1990), Develop. Brain Res., 53:125-130.
Hester Lynda
Ronnett Gabriele V.
Snyder Solomon H.
Robinson Douglas W.
The Johns Hopkins University
Ware Deborah K.
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