Method of determining metastatic potential of bladder tumor cell

Details Method of determining metastatic potential of bladder tumor cell Method of determining metastatic potential of bladder tumor cell

1994-07-27

1997-07-22

Scheiner, Toni R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, C07H 2102, C07H 2104

Patent

active

056505000

ABSTRACT:
Methods and compositions useful in the detection of human cancer cells and malignant tumors are provided. Certain human autocrine motility factor receptors or proteins (gp78-hAMFR) have been identified which are useful in the detection of human cancer cells and malignant tumors. Methods and assay kits for the detection of human cancer, human cancer cells, and tumors, are provided wherein antibodies or nucleotide hybridized probes are used to determine gp78-hAMFR expression. These methods and assays readily distinguish between non-malignant and malignant cancer cells and tumors and can be used to gauge metastatic potential.

REFERENCES:
Watanabe, H. et al., Cancer Research 51, 2699-2705, May 15, 1991, "The Relationship between Motility Factor Receptor Internalization and the Lung Colonization Capacity of Murine Melanoma Cells".
Nabi, et al., "Identification of B16-F1 Melanoma Autocrine Motility-Like Factor Receptor" Cancer Research, 50, 409-414, 1990.
Nabi, et al., Autocrine Motility Factor and its Receptor: Role in Cell Locomotion and Metastasis, Cancer and Metastasis Reviews, 11: 5-20, 1992.
Watanabe, et al., Purification of Human Tumor Cell Autocrine Motility Factor and Molecular Cloning of Its Receptro, The Journal of Biological Chemistry, 266: 13342-13448 (1991).

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