Method of determining metastatic potential of bladder tumor cell

Details Method of determining metastatic potential of bladder tumor cell Method of determining metastatic potential of bladder tumor cell

1992-07-14

1995-01-17

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436 64, 436813, 5303877, 5303888, 53038885, G01N 33574

Patent

active

053825217

ABSTRACT:
Methods and compositions useful in the screening of human bladder cancer cells and malignant tumors are provided. Certain human autocrine motility factor receptors or proteins (gp78-hAMFR) have been identified which are useful in the screening of human bladder cancer cells and malignant tumors. Methods and assay kits for the screening of human bladder cancer, human cancer cells, and tumors, are provided wherein antibodies or other probes are used which recognize gp78-hAMFR expression. These methods and assays readily distinguish between non-malignant and malignant cancer cells and tumors and can be used to gauge metastatic potential.

REFERENCES:
Watanabe, H., et al., Cancer Research 51, 2699-2705, May 15, 1991, "The Relationship between Motility Factor Receptor Internalization and the Lung Colonization Capacity of Murine Melanoma Cells."
Nabi, et al., "Identification of B16-F1 Melanoma Autocrine Motility-Like Factor Receptor Cancer Research, 50, 409-414."
Nabi, et al., Autocrine Motility Factor and its Receptor: Role in Cell Locomotion and Metastasis, Cancer and Metastasis Reviews, 11: 5-20, 1992.
Watanabe, et al., Purification of Human Tumor Cell Autocrine Motility Factor and Molecular Cloning of Its Receptor, The Journal of Biological Chemistry, 266: 13342-13448 (1991).

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