Method of determining levels of extrinsic and intrinsic clotting

Details Method of determining levels of extrinsic and intrinsic clotting Method of determining levels of extrinsic and intrinsic clotting

1989-12-19

1992-12-08

Housel, James C.

Chemistry: analytical and immunological testing

Clotting or clotting factor level tests

436 34, 436164, 436517, 436805, 436809, 435 13, G01N 3316

Patent

active

051697866

ABSTRACT:
A method of determining levels of extrinsic and intrinsic clotting factors and protein C based upon the reaction rate of the observed clot formation and the first derivative of the reaction rate of observed clot formation is provided. In accordance with the teachings of the invention, the reaction rate of the observed clot formation in a prothrombin time test or an activated partial thromboplastin time assay is determined for both test and normal plasma samples and the reaction rates compared. In another embodiment, the first derivative of the reaction rate of the observed clot formation is determined and the results compared.

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Ortho Factor VIII:C Deficient Plasma Ortho Diagnostic Systems Inc. 1988.
American Diagnostica Inc. 3X15 Test Kit for Determination of Plasma Protein C Activity Using a Clotting End-Point.
Package insert for Ortho Brain Thromboplastic Reagent.
Package insert for Ortho's Activated Thrombofax Reagent.
The American Society of Hematology 31st Annual Meeting Abstract Reproduction Form.
American Clinical Laboratory (Apr. 1989).
The Clot Signature and New Aspects in Coagulation Testing Ortho Diagnostic Systems Inc. (Aug. 1989).

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