Method of determining hypersensitivity to an allergen

Details Method of determining hypersensitivity to an allergen Method of determining hypersensitivity to an allergen

1988-02-19

1989-03-14

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 39, 435 40, 436501, 436517, 436519, 436513, C12Q 104

Patent

active

048124028

ABSTRACT:
A method is described for the in vitro determination of hypersensitivity to an allergen. The method consists of adding the allergen to a sample containing basophilic leucocytes from the blood of a patient, and then measuring the amount of degranulation of the leucocytes. The allergen is added slowly and continuously, such that the threshold concentration needed to cause degranulation of sensitized leucocytes is reached sometime during the addition step and is present for a long enough period of time to allow degranulation to occur.

REFERENCES:
Tharp, J of Immunology, 130(4), pp. 1896-1901, (1983).
Wettermark-I, J of Colloid and Interface Science, 73(1), pp. 287-289, (1980).
Wettermark-II, Derwent Abstract 59867, D/33, (1981).
Nakagawa, Allergy 36, pp. 39-47, 1981.
van Toorenenbergen, J. Immunological Methods, 49, pp. 209-213, (1982).
Benveniste, Clinical Allergy II, pp. 1-11, 1981.
Leynadier, Allergy 36, pp. 239-244, 1981.

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