Method of determining fatty acid composition of milk

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07851147

ABSTRACT:
A method of reducing the level of saturated fatty acids relative to the level of unsaturated fatty acids in milk. In particular, the genotyping and/or phenotyping of bovine cows on the basis of the amino acid residue located at position 67 of beta-casein produced in their milk. The invention is based on the finding that there is a correlation between the ratio of saturated to unsaturated fatty acids in milk and the beta-casein variants in milk.

REFERENCES:
patent: 6451368 (2002-09-01), Elliott et al.
patent: 6570060 (2003-05-01), McLachlan
patent: 7094949 (2006-08-01), McLachlan
patent: 7157616 (2007-01-01), Elliott et al.
patent: WO 96/14577 (1996-05-01), None
patent: WO 96/36239 (1996-11-01), None
patent: WO 02/19832 (2002-03-01), None
Bovenhuis, H. et al., “Associations Between Milk Protein Polymorphisms and Milk Production Traits”, 1992 J Dairy Sci 75:2549-2559.
Ikonen, T. et al., “Associations Between Milk Protein Polymorphism and First Lactation Milk Production Traits in Finnish Ayrshire Cows”, 1999 J Dairy Sci 82:1026-1033.
Laugesen, M. et al., “Ischaemic heart disease, Type 1 diabetes, and cow milk A1 β-casein”, The New Zealand Medical Journal, vol. 116 No. 1168 ISSN 1175 8716 24 Jan. 2003 pp. 1-19.
McLachlan, C.N.S., “β-casein A1, ischaemic heart disease mortality, and other illnesses”, Medical Hypotheses (2001) 56(2), 262-272.
Ojala, M. et al., “Effects of Milk Protein Genotypes on the Variation for Milk Production Traits of Holstein and Jersey Cows in California”, 1997 J Dairy Sci 80:1776-1785.
AS Truswell, “Review—The A2 milk case: a critical review”, European Journal of Clinical Nutrition (2005), 59, pp. 623-631.

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