Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-07
2008-12-16
Mertz, Prema (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S085100
Reexamination Certificate
active
07465551
ABSTRACT:
The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective dose. Measured levels of one or more cytokines in a patient subjected to cytotoxic therapy, relative to a normal population, may be used to determine the dose of a hematopoietic cytokine to be administered to the patient.
REFERENCES:
patent: 7112409 (2006-09-01), Blumenthal et al.
Chen et al. (1996). Japanese Journal of Clinical Oncology, 26(1), pp. 18-23.
Chopra et al (1998). Cancer Investigation 16(3), pp. 152-159.
Blumenthal Rosalyn D.
Goldenberg David M.
Center For Molecular Medicine and Immunology
Mertz Prema
Nakashima Richard A.
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