Method of determining calibration curve and analysis method and

Details Method of determining calibration curve and analysis method and Method of determining calibration curve and analysis method and

1997-01-08

1998-08-18

Budens, Robert D.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

435 792, 435967, 436536, 436542, G01N 3353, G01N 33566

Patent

active

057957916

ABSTRACT:
One sigmoid calibration curve is split into three parts of low concentration region represented by a high degree function, intermediate concentration region represented by an exponential function and high concentration region represented by a high degree function according to the present invention. The boundary condition of the adjacent two functions is set so that the two functions have an equal slope at the boundary point; thereby, regression functions of the calibration curves in respective regions are found. The number of standard samples for finding a calibration curve can be reduced while the calibration curve found is of high accuracy.

REFERENCES:
Rodbard, et al--Statistical Analysis of Radioimmunoassays and Immunoradiometric (Labelled Antibody) Assays--A generalized weighted, iterative least-squares method for logistic curve fitting--pp. 165-192--IAEA-SM-177/208.
Rodbard, et al--"Rapid calculation of radioimmunoassay results"--J. Lab.& Clin. Med., vol. 74 No. 5, pp. 770-781, Nov. 1969.
Canellas et al., J. Immunol. Methods 47:375-385, 1981.
Kronvall et al., APMIS 99:295-306, 1991.

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