Method of determining biological/molecular age

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C530S350000

Reexamination Certificate

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06933120

ABSTRACT:
Methods of obtaining a measurement indicative of oxidative stress and the molecular age of an individual include the step of detecting a mitochondrial DNA deletion and correlating the quantity of the deletion with a measurement of a parameter related to oxygen metabolism.

REFERENCES:
patent: 6280966 (2001-08-01), Anderson et al.
patent: 6322974 (2001-11-01), Runge et al.
Rotig et al. Deletion of mitochondrial DNA in a case of early-onset diabetes mellitus, optic atrophy, and deafness (wolfram syndrome, MIM 222300). J Clin Invest., vol. 91, pp. 1095-1098, 1993.
Wei et al. Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function. Ann. N.Y.A.Sci., vol. 854, p. 155-170, 1998.
Liu et al. Smoking-associated mitochondrial DNA mutations in human hair follicles. Environmental and Molecular Mutagenesis, vol. 30, p. 47-55, 1997.
Bai et al. Mitochondrial DNA deletions associated with aging and possibly Presbycuss: A human archival temporal Bone study. Am. J. Otology, vol. 18(4) pp. 449-453, 1997.
Lezza et al. Correlation between mitochondrial DNA 4977-bP deletions and repiratory chain enzyme activities maging human skeletal muscles. Biochem. Biophy. Res. comm., vol. 205 No. 1, pp. 272-279, 1994.
Fahn et al. Smoking-associated mitochondiral DNA mutations and Gpral Peroxidation in human lung tissues. Am. J. Respir. Cell. Mol. Biol., vol. 19, pp. 901-909, 1998.
Wei et al. Oxidative damage and mutations to mitochondiral DNA and age-dependent decline of mitochondiral respiratory function. Am. N. A. Sci., vol. 854, pp. 155-170, 1998.
Biochimica et Biophyscia Acta 1226 (1994) 37-43; Hsin-Chen Lee, et al Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing.
Mutation Research, 275 (1992) 181-193 M.N. Gadaleta, et al Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats.
American Journal of Respiratory and Critical Care Medicine, vol. 154 (1996) pp. 1141-1145 Huei-Jyh Fahn, et al Aged-related 4,977 bp Deletion in Human Lung Mitochondrial DNA.
Mutation Research, 316 (1994) 69-78 Wade Edris, et al Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA.
Mutation Research, 275 (1992) 169-180 M. Corral-Debrinski, et al Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease.
Am.J.Hum.Genet. 54:618-630, 1994 Allesandra Baumer, et al Age-related Human mtDNA Deletions: A Heterogeneous Set of Deletions Arising at a Single Pair of Directly Repeated Sequences.
Biochemical and Biophysical Research Communications, vol. 205, No. 1, 1994; Nov. 30, 1994; pp. 772-779 A.M.S. Lezza, et al Correlation Between Mitochondrial DNA 4977-bp Deletion and Respiratory Chain Enzyme Activities in Aging Human Skeletal Muscles.
Laryngoscope, vol. 106, No. 6, Jun. 1996 Michael D. Seidman, M.D., et al Association of Mitochondrial DNA Deletions and Cochlear Pathology: A Molecular Biologic Tool.
Archives of Otolaryngol—Head & Neck Surgery, vol. 123, Oct. 1997; pp. 1039-1944 Michael D. Seidman, M.D., et al Mitochondrial DNA Deletions Associated With Aging and Presbyacusis.
The American Journal of Otology, vol. 21, No. 2 (2000); pp. 161-167 Michael D. Seidman, et al Biologic Activity of Mitochondrial Metabolites on Aging and Age-Related Hearing Loss.
The Laryngoscope 110: May 2000; pp. 727-738 Michael D. Seidman, M.D. Effects of Dietary Restriction and Antioxidants on Presbyacusis.
Hearing Research 154 (2001) 73-80 Uma Bai, et al A specific mitochondrial DNA deletion (mtDNA 4977) is identified in a pedigree of a family with hearing loss.
The American Journal of Otology, vol. 18, No. 4, 1997, pp. 449-453 Uma Bai et al Mitochondrial DNA Deletions Associated With Aging Possibly Presbycusis: A Human Archival Temporal Bone Study.
The Journal of the American Medical Association, Oct. 2, 1991, vol. 266, No. 13, pp. 1812-1816 Marisol Corral-Debrinski, Ph.D., et al. Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction—Implications for Cardiac Disease.
The Laryngoscope 108: Apr. 1998; pp. 580-584 Narihisa Ueda, M.D., et al. Mitochondrial DNA Deletion Is a Predisposing Cause for Sensorineural Hearing Loss.
The Journal of Biological Chemistry, vol. 270, No. 42, Oct. 20, 1995; pp. 24769-24775 Susan M. Tanhauser, et al Multiple Deletions are Detectable in Mitochondrial DNA of Aging Mice.
The Laryngoscope 110: Dec. 2000; pp. 2123-2127 Jose M. Manaligod, M.D., et al. Age-Related Mitochondrial DNA Mutations in the Human Larynx.
Seidman MD et al. Association of Mitochondrial DNA deletions and Cochlear Pathology: A molecular biologic tool. Laryngoscope 106: 777-783, 1996.
Corral-Debrinski M et al. Association of mitochondrial DNA damage with aging and coronary atheroscerotic heart disease. Mutation Research, 275: 169-180, 1992.
Lee HC et al. Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochimica et Biophyysica Acta., 1226: 37-43, 1994.

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