Method of determining antigenically active amino acid sequences

Details Method of determining antigenically active amino acid sequences Method of determining antigenically active amino acid sequences

1994-06-01

1997-01-21

Scheiner, Toni R.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436528, 436531, 436532, 436543, 530333, 530334, 435 792, G01N 3353

Patent

active

055959156

ABSTRACT:
A method of detecting or determining a sequence of amino acids which is antigenically active within a known amino acid sequence of a protein or portion thereof comprises the steps of: synthesising a plurality of peptides, each of said peptides comprising a sequence of a plurality of amino acids which corresponds to a sequence within the known amino acid sequence, and the said peptides having overlapping amino acid sequences; contacting each of said peptides with antibody against the protein or portion of interest; and detecting or determining the presence or absence of an antigen-antibody reaction between each of said peptides and said antibody to indicate whether or not said peptide has antigenic activity.

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Lerner, Scientific American, pp. 66-74, Feb. 1983.
Kazim, A. L. et al., Biochem. J. 191, 1980, pp. 261-264.
Hopp, T. P. et al. Proc. Natl. Acad. Sci. USA 78, No. 6, Jun., 1981, pp. 3824-3828.
Gross, E. et al In The Peptides Analysis, Synthesis, Biology. vol. 2 Special Methods in Peptide Synthesis, Part A, Academic Press, N.Y. 1980 p. 21.

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