Method of determining a plasminogen activator and its inhibitor

Details Method of determining a plasminogen activator and its inhibitor Method of determining a plasminogen activator and its inhibitor

1991-05-10

1995-12-05

Redding, David A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435215, 435212, 435219, 435188, 435 692, 424 943, 514 2, 530350, C12Q 156, C12N 972, C12P 2106, A01N 3718

Patent

active

054728517

ABSTRACT:
The present invention relates to the use of a substance which inhibits the plasma proteins .alpha..sub.2 -AP and/or .alpha..sub.2 -M in the field of the determination and assay of plasminogen activators and inhibitors of said plasminogen activators. It relates in particular to a method of determining (i) a plasminogen activator selected from the group consisting of tissue plasminogen activators (tPAs) and urokinase plasminogen activators (uPAs), and (ii) an inhibitor (PAI) of said plasminogen activator, said method, which involves converting plasminogen to plasmin and then assaying the plasmin resulting from said conversion, comprising inhibition of the plasma proteins .alpha..sub.2 -antiplasmin and/or .alpha..sub.2 -macroglobulin by means of a substance selected from the group consisting of metalloproteinase materials.

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