Method of determination of pivka

Details Method of determination of pivka Method of determination of pivka

1994-04-18

1996-05-14

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 794, 435 13, 436518, 436548, 436811, G01N 33543, G01N 33573, G01N 33577

Patent

active

055166407

ABSTRACT:
To provide a simple immunochemical assay of a PIVKA of every kind (PIVKA-VII, -IX, -X, -C, -S or -Z: protein induced by vitamin K absence) corresponding to a vitamin K-dependent protein. It has been confirmed that a PIVKA of every kind can be determined according to the double antibody sandwich method wherein use is made of a solid-supported anti-PIVKA-II monoclonal antibody. There is also disclosed a reagent for determination of a PIVKA of every kind according to the above-mentioned method.

REFERENCES:
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Furukawa, M., et al. Kansaibogan ni okeru . . . , Kanzo, 1990; 31: P110.
Blanchard, R. A. et al. "Acquired Vitamin K-Dependent Carboxylation Deficiency in Liver Disease", The New England Journal of Medicine, 305(5) Jul. 30, 1981, pp. 242-248.
Soulier, J.-P., et al. "A New Method to Assay Des-.gamma.-carboxyprothrombin", Gastroenterology, 1986;91:1258-62.
Kohler, G., et al. "Derivation of specific antibody-producing tissue culture . . . ", Eur. J. Immunol., 1976. 6:511-519.
Nelsestuen G. L. "Vitamin K-Dependent Plasma Proteins." Methods in Enzymology 107:507-516, 1984.
Bray, G. L. et al. "Calcium-Specific Immunoassays for Factor IX: Reduced Levels of Antigen in Patients with Vitamin K Disorders." J. Lab. Clin. Med. 107(3) 269-278, 1986.

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