Method of detection of prostate cancer

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091100, C435S091200

Reexamination Certificate

active

10295483

ABSTRACT:
The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate adenocarcinoma.

REFERENCES:
AstraZeneca, Classification of prostate cancer (2003) ProstateLine.com, Prostate cancer, classification: pp. 1-5.
Eads, et al.,MethyLight: a High-Throughout Assay to Measure DNA Methylation, Nucleic Acids Research, 2000, vol. 27, No. 8, pp. e32, i-viii.
Brooks, et al.,CG Island Methylation Chagnes Near the GSTP1 Gene in Prostatic Intraepithelial Neoplasia, Cancer Epidemiology, Biomarkers & Prevention, Jun. 1998, vol. 7, pp. 531-536.
Goessl, et al.,DNA-Based Detection of Prostate Cancer in Blood, Urine, and Ejaculates, Annals New York Academy of Sciences, Sep. 1, 2001, vol. 945, No. 1, pp. 51-58.
Goessl, et al.,DNA-Based Detection of Prostate Cancer in Washings From Tansrectal Biopsies, Virchows Archives, 2000, vol. 439, P-400, p. 398.
Ahern, Holly,Biochemical, Reagent Kits Offer Scientists Good Return on Investment, The Scientist, Jul. 24, 1995, vol. 9, No. 15, pp. 1-5.
Goessl, et al.,Fluorescent Methylation-Specific Polymerase Chain Reaction for DNA-Based Detection of Prostate Cancer in Bodily Fluids, Cancer Research, Nov. 1, 2001, vol. 60, pp. 5941-5945.
Chu, et al.,The Use of Real-Time Quantitative Polymerase Chain Reaction toDetect Hypermethylation of the CPG Islands in the Promoter Region Flanking the GSTP1 Gene to Diagnose Prostate Carcinoma, The Journal of Urology, Apr. 2002, vol. 167, pp. 1854-1858.

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