Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2002-04-25
2008-08-19
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C536S023100, C435S320100
Reexamination Certificate
active
07413873
ABSTRACT:
The present invention is based, in part, on the discovery that colon carcinoma, carcinogenesis, or the predisposition thereto is associated with the level of Wnt2, Wnt5, BMP6, and Fz receptors and the full-length and dominant negative form of LEF1.
REFERENCES:
Hsu et al (1998, Molecular and Cellular Biology, vol. 18, No. 8, pp. 4807-4818).
NCBI accession No. AF198532 (PRI Nov. 25, 1999).
Hovanes et al., (May 2001, Nature Genetics, vol. 28, pp. 53-57).
Waterman et al., Genes Dev. Apr. 1991;5(4):656-69.
Voet et al., (Biochemistry, John Wiley & Sons, 1990, pp. 835-837 only).
The sequence alignment of GenEmbl Accession No. AF288571 (Aug. 20, 2000, Hovanes et al) against nucleotides 999-1854 of the instant SEQ ID No. 3.
The sequence alignment of GenEmbl Accession No. AF288571 (Aug. 20, 2000, Hovanes et al) aginst a polynucleotide encoding the instant SEQ ID No. 5.
The sequence alignment of GenEmbl Accession No. AP002077 (Aug. 10, 2000) against nucleotides 153-201 of SEQ ID No. 1.
The sequence alignment of GenEmbl Accession No. AF198532 (Nov. 25, 1999) against a polynucleotide encoding the instant SEQ ID No. 5.
Bienz and Clevers, “Linking Colorectal Cancer to Wnt Signaling”,Cell, vol. 103, pp. 311-320, 2000.
Cadigan, Kenneth M. et al., “Wingless Repression ofDrosophila frizzled 2Expression Shapes the Wingless Morphogen Gradient in the Wing”,Cell, vol. 93, pp. 767-777, 1998.
Groden, Joanna et al., “Identificationa nd Characterization of the Familial Adenomatous Polyposis Coli Gene”,Cell, vol. 66, pp. 589-600, 1991.
Heslip, Tim R. et al., “Shaggy and Dishevelled exert opposite effects onwinglessanddecapentaplegicexpression and non positional identity in imaginal discs”,Developmentl, vol. 124, pp. 1069-1078, 1997.
Hirsinger, Estelle et al., “Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning”,Development, vol. 124, pp. 4605-4614, 1997.
Hooper, Joan E., “Distinct pathyways for autocrine and paracrine Wingless signallingDrosophilaembryos”,Nature, vol. 372, 1994.
Hovanes, K et al., “The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing”,Nucleic Acids Research, vol. 28, pp. 1994-2003, 2000.
Kinzler, Kenneth W. et al, “Identification of FAP Locus Genes from Chromosome 5q21”,Reports, pp. 661-665, 1991.
Korinek, Vladimir et al., “Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC-\-Colon Carcinoma”, Science, vol. 275, pp. 1784-1787, 1997.
Molenaar, Miranda et al., “XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos”,Science, vol. 280, pp. 1564-1569, 1998.
Noordermeer, Jasprien et al., “The consequences of ubiquitous expression of thewinglessgene in theDrosophilaembryo”,Development, vol. 116, pp. 711-719, 1992.
Polakis, Paul, “Wnt signaling and cancer”,Genes&Dev., vol. 14, pp. 1837-1851, 2000.
Prieve and Waterman, “Nuclear Localization and Formation of β-Catenin-Lymphoid Enhancer Factor 1 Comlexes Are Not Sufficient for Activation of Gene Expression”,Molecular and Cellular Biology, vol. 19, No. 6, pp. 4503-4515, 1999.
Riggins, Greogry J. et al., “Mad-related genes in the human”,Nature Genetics, vol. 13, pp. 461-464, 1996.
Roose, Jeroen et al., “Synergy Between Tumor SuppressorAPCand the β-Catenin-Tcf4 TargetTcf1”, Science, vol. 285, pp. 1923-1926, 1999.
Theisen, Heidi et al., “Developmental territories created by mutual antogonism between Wingless and Decapentaplegic”,Development, vol. 122, pp. 3939-3948, 1996.
Van de Wetering, Marc et al., “Extensive Alternative Splicing and Dual Promoter Usage Generate Tcf-1 Protein Isoforms with Differential Transcription Control Properties”,Molecular and Cellular Biology,vol. 16, No. 3, pp. 745-752, 1996.
Holcombe Randall F.
Hovanes Karine
Li Tony Wai Hung
Marsh J. Lawrence
Waterman Marian L.
DLA Piper (US) LLP
The Regents of the University of California
Yu Misook
LandOfFree
Method of detection and treatment of colon cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of detection and treatment of colon cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of detection and treatment of colon cancer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4001557