Method of detection and disease state management for renal...

Chemistry: analytical and immunological testing – Test for named disease – body condition or organ function

Reexamination Certificate

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C435S007100, C435S007920, C436S501000

Reexamination Certificate

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07109044

ABSTRACT:
The present invention relates to a method of detection of an early-stage renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid sample taken from a subject and comparing the determined concentration with a reference value set by determining the concentrations of human lipocalin-type prostaglandin D synthase in body fluid samples taken from healthy subjects; and a method of disease state management for a renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid sample taken from a subject and evaluating the glomerular filtration ability of the subject from the determined concentration.

REFERENCES:
patent: 6122540 (2000-09-01), Katzberg et al.
patent: 0913405 (1999-05-01), None
Andrea H., “Molecular Characterization of β-Trace Protein in Human Serum and Urine: A Potential Diagnostic Marker for Renal Diseases”, Glycobiology, vol. 7, No. 4, p. 499-506 (1997).
Priem Friedrich et al., “beta-Trace protein in serum: A new marker of glomerular filtration rate in the creatinine-blind range”,Clinical Chemistry, vol. 45, No. 4, pp. 567-568 XP-001080031, Apr. (1999).
Chemke J et al., “Pre Natal Diagnosis of Meckel Syndrome Alpha Feto Protein and Beta Trace Protein in Amniotic Fluid”,Clinical Genetics, vol. 11, No. 4, pp. 285-289, XP-002202028, (1977).

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