Method of detecting variant nucleic acids

Details Method of detecting variant nucleic acids Method of detecting variant nucleic acids

1994-03-03

1997-02-25

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, C12Q 168, C12P 1934

Patent

active

056057946

ABSTRACT:
Method of detecting nucleic acids whose nucleotide sequences differ from one another at a position X. The method uses a set of oligonucleotides where the nucleotides found at position X are complementary to a variant nucleic acids only at this position X. However, with respect to the position of another mismatch Y, the nucleotide sequences thereof differ from one another. The invention further addresses reagents for performing the methods as well as reagents and applications of the method.

REFERENCES:
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Nucl. Acids Res. 17, 8093-8099 (1989).
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Biochem. Biophys. Res. Commun. 160, 441-447 (1989).
Proc. Nat. Acad. Sci. USA 82, 1585-1588 (1985).
New England Journal of Medicine 317, 985 (1987).
Nucl. Acids Res. 17, 2437-2448 (1989).
Proc. Natl. Acad. Sci. USA 88, 189-193 (1991).
Nucl. Acids Res. 16, 11141-11151 (1988).

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