Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-04-05
1999-12-07
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 2, 424 5, 435 792, 435 793, 436149, 436811, G01N 3353, G01N 100, A61K 4904
Patent
active
059981490
ABSTRACT:
This invention provides an improved assays for the detection of transmissible spongiform encephalopathies (TSEs) in humans and non-human mammals. The methods involve detecting the presence or absence of 14-3-3 proteins in cerebrospinal fluid from the tested organism. Elevated levels of 14-3-3 are indicative of transmissible spongiform encephalopathies, in particular Creutzfeldt-Jacob disease in humans or mad cow disease in bovines).
REFERENCES:
patent: 4892814 (1990-01-01), Harrington et al.
patent: 5270165 (1993-12-01), Van Nostrand et al.
Ichimura et al "Widespread Distributuion of the 14-3-3 Protein in Vertibrate Brains and Bovine Tissues: Correlation with the Distribution of Calcium-Dependent Protein Kinases" J. Neurchem 56:1449-1541 (1991).
Gibbs Clarence J.
Harrington Michael G.
Hsich Gary
Kenney Kimbra
Housel James C.
Swartz Rodney P.
The United States of America as represented by the Department of
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