Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-12-09
1995-10-17
Parr, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 723, 435 794, 436503, 436811, 436813, 5303888, 53038824, 530403, 530828, 5303891, 536 231, 935 3, C12Q 168, C12Q 100, C07K 1500, C07H 1700
Patent
active
054590353
ABSTRACT:
A method is described for identifying and localizing tumors in a patient. The method comprises assaying extracellular fluids, isolated from a patient, for the presence of elevated levels of ring shaped particles (RSP). The assay employs binding labeled RSP specific binding agent to the RSP.
REFERENCES:
patent: 3798131 (1974-03-01), Rounds et al.
patent: 5059521 (1991-10-01), Scherrer et al.
Dang, Cell Biology International Reports, vol. 8, No. 4, 1984, pp. 323-327.
Leary, J. J. et al., Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose: bio-blots, Proc. Natl. Acad. Sci. USA, 80, 4045-4049, Jul., 1983.
Forster, A. C. et al., Non-radioactive hybridization probes prepared by the chemical labelling of DNA and RNA with a novel reagent, photobiotin, Nucleic Acids Research, vol. 13 No. 3, 745-761, 1985.
Shelton, E. et al., Cytoplasmic Particles and Aminoacyl Transferase I Activity, The Journal of Cell Biology, vol. 45, 1-8, 1970.
Harris, J. R., Comparative Studies on Cylindrin: Identity with Aminoacyl-tRNA Synthetase, Micron Microscop. Acta 14, 193-205, 1983.
Domae, N. et al., Novel Donut-Shaped "Miniparticles" in Nuclei of Human and Rat Cells, Life Sciences 30:469-477, 1982.
Davis, F. M. et al., Nucleolar antigen found in several human tumors but not in the y ynnontumor tissues studies, Proc. Natl. Acad. Sci. USA, vol. 76, No. 2, pp. 892-896, Feb., 1979.
Kumatori, A. et al., Abnormally high expression of proteasomes in human leukemic cells, Proc. Natl. Acad. Sci. USA, vol. 87, pp. 7071-7075, Sep. 1990.
Narayan, K. S. et al., Occurrence of Minute Ring-Shaped Nucleoprotein Particles in Culture Media Conditioned By Mammilian Cells, in Vitro, vol. 12, No. 6, 436-441, 1976.
Narayan, K. S. et al., Minute Ring-shaped Particles in Cultured Cells of Malignant Origin, Nature New Biology vol. 243, 146-150, May 30, 1973.
Rounds, D. E., et al., Prospects for a Personal Screening Method for Cervical Carcinoma, Gynecologic Oncology 4, 125-132, 1976.
Rounds, D. E., et al., Production of Ring-Shaped Particles by Normal and Metaplastic Tissue. I. Human Skin, Journal of the National Cancer Institute, vol. 55, No. 1, 7-10, Jul., 1975.
Rounds, D. E., A Growth-modifying Factor from Cell Lines of Human Maglinant Origin, Cancer Research 30, 2847-2851, Dec., 1970.
Deutscher, M. P., The Eucaryotic Aminoacyl-tRNA Synthetase Complex: Suggestions for its Structure and Function, The Journal of Cell Biology, vol. 99, 373-377, Aug., 1984.
Reisfeld, A., et al., Nonradioactive Hybridization Probes Prepared By the Reaction of Biotin Hydrazide with DNA.sup.1, Biochemical and Biophysical Research Communications, vol. 142, No. 2, 519-526, Jan. 30, 1987.
Dang, C. V., Identity of the Ubiquitous Eukaryotic Ring-Shaped Miniparticle, Cell Biology International Reports, vol. 8, No. 4, 323-327, Apr., 1984.
Smulson, M., Subribosomal Particles of HeLa Cells, Experimental Cell Research 87, 253-258, 1974.
Kleinschmidt, J. A. et al., The 22 S cylinder particles of Zenopus Laevis, I. Biochemical and electron microscopic characterization, European Journal of Cell Biology 32, 143-156, 1983.
Harmon, F. R. et al., Purification and Partial Characterization of Ring-shaped Miniparticles, Cell Biology Intl. Reports, vol. 7, No. 5, 333-343, May, 1983.
Busch, H. et al., Ultrastructural and Purification Studies on Human Tumor Nucleolar Antigens and Nucleolar Particles, Cancer Investigation, 1(1), 25-40, 1983.
Busch, H. et al., A Nucleolar Antigen Found in a Broad Range of Human Malignant Tumor Specimens, Cancer Research 39, 3024-3030, Aug., 1979.
Wieczorek, A. J. et al., Diagnostic and Prognostic Value of RNA-Proteolipid in Sera of Patients with Malignant Disorder following Therapy: First Clinical Evaluation of a Novel, Tumor Marker, Cancer Research 47, 6407-6412, Dec. 1, 1987.
Wieczorek, A. J. et al, Ein Gensondentest fur RNA-Proteolipid in Serumproben bei Neoplasie, Schweiz, Wschr. med. 1989: 119; 1342-1343 (with attached translation).
Peters, J. M. et al., An Abundant and ubiquitous homooligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec 18p and NSF, The EMBO Journal, vol. 9, No. 6, 1757-1767, Jun., 1990.
Busch, H. et al., A Nucleolar Antigen Found in a Broad Range of Human Malignant Tumor Specimens.sup.1, Cancer Research 39, vol. 39, 3024-3030, Aug. 1979.
Soel, J. H. et al., Na+, K+-specific inhibition of protein and peptide hydrolyses by proteasomes from hyuman hepatoma tissues, Febs Letters, vol. 247, No. 2, 197-200, Apr. 1989.
Tanaka, K. et al., Proteasomes (Multicatalytic Proteinase Complexes) in Eukaryotic Cells, Cell Structure and Function 15, 127-132 (1990).
Guerrero Robert R.
Rounds Donald E.
AMDL, Inc.
Parr Margaret
Sisson Bradley L.
LandOfFree
Method of detecting the tumors using ring shaped particles as a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of detecting the tumors using ring shaped particles as a , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of detecting the tumors using ring shaped particles as a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-596530