Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1980-10-28
1982-09-14
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435875, C12Q 110, C12R 1385
Patent
active
043496261
ABSTRACT:
A novel method of detecting and diagnosing Pseudomonas aeruginosa infections by monitoring sample headspace concentrations of selected methyl ketones, particularly 2-nonanone and 2-undecanone. In an alternate embodiment, such diagnosis may be made by monitoring the headspace concentration of methyl mercaptan to diagnose the extent of a Pseudomonas aeruginosa infection. Expeditious methods for increasing such concentrations are also disclosed which include additions of selected nutrients to incubated sample mixtures.
REFERENCES:
Moss, C. W. and S. B. Dees, 1976 "Cellular Fatty Acids and Metabolic Products of Pseudomonas Species Obtained from Clinical Specimens"; Journal of Clinical Microbiology 4: 492-502.
Wade, T. J. and R. J. Mandel, 1974, "New Gas Chromatographic Charecterization Procedure: Preliminary Studies on Some Pseudomonas Species" Applied Microbiology 27: 303-311, Feb. 1974.
Charles D. Cox and J. Parker, "Use of 2-aminoacetophenone Production in Identification of Pseudomonas aeruginosa", Apr. 1979 9: 479-484, Journal of Clinical Microbiology.
"Development of Specific Tests for Rapid Detection of E. coli and Species of Proteus in Urine", by N. J. Hayward, et al., Journal of Clinical Microbiology, Sep. 1977 6: 195-201.
"Volatile Compounds Produced in Sterile Fish (Sebastes malanops) by Pseudomonas putrefaciens, Pseudomonas fluorescens, and an Archromobater Species", by Miller et al., Applied Microbiology, 26: 18-21 Jul. 1973.
"High Resolution Gas Chromatographic Profiles of Volatile Organic Compounds Produced by Microorganisms at Refrigerated Temperatures", by Lee, et al., Applied and Environmental Microbiology No. 1 37: 85-90, Jan. 1979.
"Epidemiology of Pseudomonas aeruginosa Infections: Determination by Pyocin Typing", by Brunn, et al. (1976), Journal of Microbiology, 3:264-271.
"Pseudomonas Carrier Rates of Patients with Cystic Fibrosis and of Members of their Families", by Laraya-Cuasay, et al., Journal of Pediatrics, 89:23-26 (1980).
"Gas Chromatography Application in Microbiology and Medicine", by Mitruka (1979), John Wiley and Sons, New York, Chapter 13, pp. 352-374.
"Further Studies on the Differentiation of Clostridium sordelli from Clostridium bifermentans by Gas Chromatography", (1970), Canadian Journal of Microbiology 16:1071-1078 Brooks, et al.
"Analysis by Gas Chromatography of Hydroxy Acids Produced by Several Species of Neisseria", Canadian Journal of Microbiology 18:157-168 (1972) Brooks, et al.
"Analysis by Gas Chromatography of Fatty Acids found in Whole Cultural Extracts of Neisseria Species", Can. J. Microbiol. 17:531-541 (1970).
"Botulism: A Pyrolysis-Gas-Liquid Chromatographic Study", J. Chromatogr. Sci. 16: 623.629 (1978).
"Quantitative Methods for the Gas Chromatographic Characterization of Acidic Fermentation By-Products of Anaerobic Bacteria", by Bohannon, et al., J. of Chromatogr. Sci. 16: 28-35 (1978).
"Analysis of Amines and Other Bacterial Products by Head-Space gas Chromatography" by Larsson, et al., Acta Path. Microbiol. Scand. Section B 86: 207-213.
"Methylmercaptan and DMDS Production from Methionine by Proteus Species Detected by Head-Space Gas-Liquid Chromatography" by Hayward, et al., J. of Clin. Microbiol. 6: 187-194 (1977).
"Characteristic Gamma-Lactone Odor Production of the Genus Pityrosporum" by Labows, et al., Appl. and Environ. Micro. 38: 412-415 (1979).
"The Chemistry of Some Microbially-Induced Flavor Defects in Milk and Dairy Foods", by Morgan, Biotech. Bioeng. 18:953-965 (1976).
Kostelc, et al. "Salivary Volatiles as Indicators of Periodontitis" J. Periodont. Res. 18: 185-192 (1980).
Matsumota, et al., "Identification of Volatile Compounds in Human Urine", J. Chromatogr. 85: 31-34 (1973).
Zlatkis, et al., "Concentration and Analysis of Volatile Urinary Metabolites" J. Chromatogr. Sci. 11:299-302 (1973).
Liebich, et al., "Volatile Substances in Blood Serum: Profile Analysis and Quantitative Determination" J. Chromatogr. 142: 505-516 (1977).
van den Dool, et al., "A Generalization of the Retention Index System Including Linear Programmed Gas-Liquid Chromatography", J. of Chromatography, vol. 11, pp. 463-471 (1963).
Withycombe, et al., "Isolation and Identification of Volatile Components from Wild Rice Grain" J. of Agricultural Food Chemistry, vol. 6, pp. 816-821 (1978).
Tonzetich, "Direct Gas Chromatographic Analysis of Sulfur Compounds in Mouth Air in Man", Archives of Oral Biology, vol. 16, pp. 587-597 (1971).
Budzikiewicz, et al., "Mass Spectrometry of Organic Compounds", p. 155, Holden-Day, Inc., San Francisco (1967).
Dwivedi, et al. "Carbonyl Production from Lipolyzed Milk Fat by the Continuous Mycelial Culture of Penicillium roqueforti", J. Food Science, 39: 83-137 (1974).
Burger et al., "Ketones from the Pedal Gland of the Bontebok", Z. Naturforsch C: Bioscience 316: (1-2):21-8.
Albone et al., "Bacteria as a Source of Chemical Signals in Mammals", reprinted pp. 35-43 in D. MullerSchwarze and M. M. Mozell, editors, Chemical Signals in Vertebrates, Plenum Press, N. Y. (1977).
Ikeshoji, "Bacterial Production of the Ovipositional Attractants for Mosquitos on Fatty Acid Substrates", Appl. Ent. Zool. 10:239-242.
John N. Labows, K. J. McGinley, Guy F. Webster, & J. J. Leyden, "Headspace Analysis of Volatile Metabolites of Pseudomonas aeruginos and Related Species by Gas Chromatography-Mass Spectrometry".
Gorbach, S. L., J. W. Mayhew, J. G. Bartlett, H. Thadepalli, and A. B. Onderdonk. 1976, Rapid Diagnosis of Anaerobic Infections by Direct Gas-Liquid Chromatography of Clinical Specimens. J. Clin. Invest. 57:478-484.
Kostelc James G.
Labows John N.
McGinley Kenneth J.
The Monell Chemical Senses Center
Warden Robert J.
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