Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1994-05-13
1996-10-15
Stanton, Brian R.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
424 91, 435 5, 435 29, 435 691, 435 697, 435 711, 4351723, 43524021, 4353201, 536 231, 536 234, 536 235, 536 2372, 800 2, 800DIG1, C12N 1509, C07H 2104, A61K 4900, G01N 3300
Patent
active
055651860
ABSTRACT:
Prions are protein based infectious material that cause of variety of diseases such as Scrapie, bovine spongiform encephalopathy (also known as "Mad Cow" disease), Creutzfeldt Jakob Disease, Kuru, and fatal familial insomnia. The invention is directed to artificial prion genes that are made up of elements of the prion genes of a host and test species. When these artificial prion genes are inserted into a transgenic mouse, the resultant mouse becomes susceptible to infection with prions that infect the test species but do not normally infect mice. The transgenic animals are useful for testing for the presence of prions in a sample.
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Prusiner Stanley B.
Scott Michael R.
Telling Glenn
Bozicevic Karl
Stanton Brian R.
The Regents of the University of California
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