Method of detecting neutophil inhibitory factor mimics

Details Method of detecting neutophil inhibitory factor mimics Method of detecting neutophil inhibitory factor mimics

1993-12-23

1998-05-05

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 71, 435 79, 435 792, 424851, 424327, 424527, 514 2, 514 8, 530351, 530355, G01N 3353, A61K 39002, C07K 1444

Patent

active

057472963

ABSTRACT:
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.

REFERENCES:
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Proc. Natl. Acad. Sci. vol. 88, pp. 3106-3110, Apr. 1991. Dana et al.
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Hodgson Bio/ Technology vol. 10, pp. 973-977 Oct. 1992.
Mileski et al. Surgery vol. 108(2) 206-212 Aug. 1990.
Michishita et al. Cell vol. 72, 857-867 Mar. 26, 1993.
Dana et al. Proc. Natl. Acad. Sci USA vol. 88, 3106-16 Apr. 1991.

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