Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-04-15
2000-05-23
Zitomer, Stephanie
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 2433, C12Q 168, C12P 1934, C07H 2104, C07H 2102
Patent
active
060664495
ABSTRACT:
This invention provides a method of detecting metastatic thyroid cancer in a subject which comprises detecting circulating thyroid cells in a bodily fluid sample of the subject by obtaining an appropriate nucleic acid sample from the bodily fluid sample of the subject; and determining whether the nucleic acid sample contains a marker sequence. Specifically, this invention provides wherein the marker sequence is mRNA corresponding to the reverse transcript of DNA encoding thyroglobulin. Also, this invention provides wherein the marker sequence is mRNA corresponding to the reverse transcript of DNA encodes thyroid peroxidase. This invention further provides a test kit for performing the above-described method.
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Chabot John A.
Ditkoff Beth Ann
Feind Carl R.
LoGerfo Paul
The Trustees of Columbia University in the City of New York
White John P.
Zitomer Stephanie
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