Method of detecting lung disease

Details Method of detecting lung disease Method of detecting lung disease

1995-07-31

1997-05-13

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424489, 424 91, A61K 31495, C08K 53462

Patent

active

056289847

ABSTRACT:
A method of faciltating the obtaining of a mucus sample from at least one lung of a subject comprises administering a physiologically acceptable salt to at least one lung of the subject in an amount effective to hydrate lung mucus secretions therein, and concurrently administering to said at least one lung of the subject, in an amount effective to hydrate lung mucous secretions therein, uridine triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof. Pharmaceutical compositions useful for carrying out the method comprise, in combination, a physiologically acceptable salt, and uridine triphosphate, an active analog thereof, or a pharmaceutically acceptable salt of either thereof. The composition may be a liquid composition or a dry powder composition.

REFERENCES:
patent: 4501729 (1985-02-01), Boucher et al.
patent: 5292498 (1994-03-01), Boucher, Jr.
patent: 5420116 (1995-05-01), Puchelle
M.I. Lethem et al,; Nucleotide Regulation of Goblet Cells in Human Airway Epithelial Explants: Normal Exocytosis in Cystic Fibrosis, Am. J. Respir. Cell Mol. Biol. 9, 315-322 (1993).
K.N. Olivier, Acute Safety and Effects on Mucociliary Clearance of Aerosolized Clearance of Aerosolized Uridine 5'-Triphosphate .+-. Amiloride in Normal Human Adults, Am. J. Respir. Crit. Care Med. 154, 217-223 (1996).

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