Method of detecting ligand interactions

Details Method of detecting ligand interactions Method of detecting ligand interactions

1994-06-16

1997-06-03

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

424 932, 4352523, 43525231, 43525233, 43525411, 435697, 4351723, 530327, 530330, 530350, 536 231, 536 234, 935 79, 935 80, A61K 3900, C12N 1562, C12N 1500

Patent

active

056351828

ABSTRACT:
Provided by the present invention are novel methods of detecting ligand interactions, as well as regents useful in the method, including DNA and host cells; and more specifically relates to novel methods for the detection of protein/protein interactions and their application in epitope mapping and the study of ligand/receptor interactions. Also provided are vaccines and kits comprising the expression products and host cells of the invention.

REFERENCES:
patent: 4801536 (1989-01-01), Stahl et al.
patent: 5270181 (1993-12-01), McCoy et al.
patent: 5292466 (1994-03-01), McCoy et al.
patent: 5292646 (1994-03-01), McCoy et al.
patent: 5457038 (1995-10-01), Trinchieri et al.
Gubler et al. 1991 Proc. Natl. Acad. Sci., USA 88:4143-4147.
Wakasugi et al., Proc. Nat'l. Acad. Sci. U.S.A. 87:8282-8286 (1990).
Bardwell et al., Cell 67:581-589 (1991).
Bennett et al., Nature 334:268-270 (1988).
Mazzarella et al., J. Biol. Chem. 265:1094-1101 (1990).
LaVallie et al., Bio/Technology 11:187-193 (1993).
Ellis et al., Biochemistry 31:4882-91 (1992).
Eklund et al., EMBO J. 3:1443-1449 (1984).
Holmgren, J. Biol. Chem. 264:13963-13966 (1989).
Lim et al., J. Bacteriol. 163:311-316: (1985).
Xia, Protein Science 1:310-321 (1992).
Maniatis et al., Molecular Cloning. A Laboratory Manual. (1982) Cold Spring Harbor Laboratory.
Smith, Science 228:1315-1317 (1985).
Scott et al., Science 249:386-390 (1990).
Parmley et al., Gene 73:305-318 (1988).
Djojonegoro et al., Bio/Technology 12:169-172 (1994).
Oldenberg et al., Proc. Nat'l. Acad. sci. U.S.A. 89:5393-5397 (1992).
Scott et al., Proc. Nat'l. Acad. Sci. U.S.A. 89:5398-5402 (1992).
Blond-Elguindi et al., Cell 75:717-728 (1993).
Hammer et al., J. Exp. Med. 176:1007-1013 (1992).
Wilson et al., Can. J. Microbiol. 39:451-472 (1993).
Joys, Can J. Microbiol. 34:452-458 (1988).
Sanger et al., J. Mol. Biol. 162:729-773 (1982).
Edman et al., Nature 317:267-270 (1985).
Brent et al., Proc. Nat'l. Acad. Sci. 78:4204-4208 (1981).
Russell et al., J. Bacteriol. 171:2614-2618 (1989).
Hamilton et al., J. Bacteriol. 171:4617-4622 (1989).
Blair et al., J. Bacteriol. 173:4049-4055 (1991).
Norrander et al., Gene 26:101-106 (1983).
Newton et al. "Expression and immunogenicity of a streptococcal M protein epitope inserted in Salmonella flagelin" Infection and Immunity 59: 2158-2165.
Yu et al. "Identification and nu8cleotide sequence of the activator gene of the externally induced phosphoglycerate transport system of Salmonella typhimurium" Gene 45: 51-57.
Revell et al. "Nucleotide sequence and expression in Escherichia coli of cDNAs encoding papaya proteinase omega from Carica papaya". Gene 127:221-225.
Toh et al. "The 60-to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a .beta. subunit of the gastric H+/K+-ATPase (proton pump)". Proceedings of the National Academy of Sciences, USA 87: 6418-6422.
Stocker, "Aromatic-dependent Salmonella as live vaccine presenters of foreign epitopes as inserts in flagelin" Res. Microbiol 141: 787-796.

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