Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1975-10-01
1978-07-11
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 424 8, 424 12, 424 86, 424 89, 424 93, A61K 3900, A61K 3942, A61K 4300, G01N 3100
Patent
active
041002679
ABSTRACT:
The formation of antibodies to the A-2 plaque virus previously propagated in tissue culture is described. The application describes an immune response against those antibodies and against the A-2 plaque virus antigen which is associated with human viral hepatitis both of type A and B origin. The reaction of antibody for A-2 plaque virus with the antigen from stool specimens of volunteers infected with type A hepatitis and from the sera of patients diagnosed as having type B hepatitis is described. Convalescent sera from both type A and type B hepatitis patients in reaction with the virus, demonstrate the presence of antigenic components in the plaque virus which react with human antibody formed in response to infection with either type A or type B hepatitis. Moreover, the A-2 plaque antibodies react with hepatitis B core antigen, while antibodies to HB.sub.c Ag react with A-2 plaque antigen. Additionally, methods for inducing antibody formation in humans from the A-2 plaque virus antigen are described, as are methods for detecting HB.sub.c Ag, HB.sub.c Ab, HAAg and HAAb.
REFERENCES:
CDC, Morbidity & Mortality, HEW vol. 23, No. 4, Date of Release, Feb. 1, 1974, p. 29.
Shaw et al., Abstract of "Studies of A-2 Plaque Virus in Asso. with Viral Hepatitis", Program of ASCP, Fall Meeting Oct. 4-11, 1974, 1 page.
Almeida, Lab.-Lore, Welcome Service in Lab. Tech., Welcome Reagents, Burroughs Welcome Co., N. C., vol. 6, No. 6, Feb. 1975, pp. 337-340.
Shaw, J. of Virology, vol. 12, No. 6, Dec. 1973, pp. 1598-1607.
Shaw.sup.(2), IX Int. Cong. for Microbiology, Moscow, USSR, Abstract of Papers, 1966, p. 395.
Fagelson A. P.
Meyers Albert T.
Ortho Diagnostics Inc.
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