Method of detecting directly undetectable analytes using...

Details Method of detecting directly undetectable analytes using... Method of detecting directly undetectable analytes using...

2011-05-31

2011-05-31

Neckel, Alexa D (Department: 1795)

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

C204S645000

Reexamination Certificate

active

07951278

ABSTRACT:
The present invention provides a method of indirectly detecting at least one directly undetectable analyte of interest. According to the method, a leading electrolyte and a trailing electrolyte are provided. In addition, a mixture of the at least one directly undetectable analyte and at least two directly detectable spacer molecules is provided. The directly detectable spacer molecules and the directly undetectable analyte are then concentrated and separated into zones using isotachophoresis. A displacement between the zones of directly detectable spacer molecules is then used to determine the presence of the directly undetectable analyte.

REFERENCES:
patent: 3948753 (1976-04-01), Arlinger
patent: 2005/0121324 (2005-06-01), Park et al.
patent: 2005/0133370 (2005-06-01), Park et al.
Nagoyova, Iveta et al. “Discrete Spacers for Photometric Characterization of Humic Acids Separated by Capillary Isotachophoresis.” 2001. Journal of Chromatography A, pp. 191-200.
Oerlemans, F. et al. “Isotachophoresis of Urinary Purines and Pyrimidines: The Use of Spacers and Enzymes for Identification.” 1981. Journal of Chromatography 225, pp. 369-379.
Gross, Larry et al. “Indirect Fluorometric Detection of Cations in Capillary Zone Electrophoresis.” 1990. American Chemical Society, pp. 427-431.
Schafer-Nielsen et al. Separation of Macromolecules in Isotachophoresis Systems Involving Single or Multiple Counterions, Journal of Biochemical and Biophysical Methods, 3 (1980) 97-128.

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