Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-09-15
1996-12-17
Spiegel, Carol A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 724, 435 725, 435 79, 435 792, 435 795, 436519, 436520, G01N 33567
Patent
active
055852432
ABSTRACT:
Drug-dependent antibodies that bind to granulocytes, erythrocytes, platelets or membrane proteins derived from these cells, in the presence of a drug, but not in its absence, can be detected using a sensitive assay. Detection of the drug-dependent antibodies permits diagnosis of cytopenia mediated by the drug.
REFERENCES:
patent: 4717654 (1988-01-01), Savoca et al.
Logue et al., New England Journal of Medicine, vol. 283 No. 17, pp. 900-904 (Oct. 22, 1970).
Levitt, Blood, vol. 69 No. 2, pp. 394-400 (Feb. 1987).
A. V. Pisciotta et al, "Cytotoxic Activity In Serum of Patients With Clozapine-Induced Agranulocytosis", J. Lab. Clin. Med. 119(3):254-266 (1992).
A. Salama et al, "Immune-mediated Agranulocytosis Related to Drugs and Their Metabolites: Mode of Sensitization and Heterogeneity of Antibodies", Br. J. of Haematology 72:127-132 (1989).
H. E. Hamilton et al, "Sulfisoxazole-Induced Thrombocytopenic Purpura", JAMA 238(24):2586-2587 (1978).
F. W. A. Verheugt et al, "Autoimmune Granulocytopenia: the Detection of Granulocyte Autoantibodies with the Immunoflourescence Test", Br. J. of Haematology 39:339-350 (1978).
G. P. Visentin et al, "Detection of Drug-Dependent, Platelet-Reactive Antibodies by Antigen-Capture ELISA and Flow Cytometry", Transfusion 30(8):694-700 (1990).
S. A. Weitzman et al, "Drug-Induced Immunological Neutropenia", The Lancet 1068-1071 (May 20, 1978).
C. H. Packman et al, "Drug-Related Immunologic Injury of Erythrocytes", in W. J. Williams et al (eds.) Hematology Chapter 69:681-686 (4th edition McGraw Hill 1990).
S. Karpatkin, "Drug-Induced Thrombocytopenia", The American J. of The Medical Sciences 262(2):68-78 (1971).
T. Hackett et al, "Drug-Induced Platelet Destruction", Seminars in Thrombosis and Hemostasis 8(2): (1982). pp. 116-137.
B. H. Chong, "Drug-Induced Immune Thrombocytopenia", Platelets, 2: 173-181 (1991).
C. Mueller-Eckhardt et al, "Drug-Induced Immune Cytopenias: A Unifying Pathogenetic Concept With Special Emphasis on the Role of Drug Metabolites", Transfusion Medicine Reviews 4(1):69-77 (1990).
J. N. George, "Drug-Induced Immunologic Thrombocytopenia", in W. J. Williams et al (eds.) Hematology Chapter 130:50-64.
V. Kiefel et al, "Metabolite-Specific (IgG) and Drug-Specific Antibodies (IgG, IgM) in Two Cases of Trimethoprim-Sulfamethoxasole-Induced . . . ", Transfusion 27(3):262-265 (1987).
M. Karpatkin et al, "The Platelet Factor 3 Immunoinjury technique Re-evaluated . . . ", J. Lab. Clin. Med. 80(2):400-408 (1977).
P. L. Cimo et al, "Detection of Drug-Dependent Antibodies by the .sup.51 Cr Platelet Lysis Test", Amer. J. of Hematology 2:65-72 (1977).
J. G. Kelton et al, "Drug-Induced Thrombocytopenia is Associated With Increased Binding of IgG to Platelets Both In Vivo and In Vitro", Blood 58(3):524-529 (1981).
J. E. Menitove et al, "Cyclic Thrombocytopenia of Apparent Autoimmune Etiology", Blood 73(6):1561-1569 (1989).
A. Salama et al, "Immune-Mediated Blood Cell Dyscrasias Related to Drugs", Seminars in Hematology 29(1):54-63 (1992).
N. R. Shulman et al, "Platelet Immunology", in R. W. Coleman et al (eds.) Hemostasis and Thrombosis (second edition J.B. Lippincott Co.) Chapter 27:452-529 (1987).
"Thrombocytopenia Due to Platelet Destruction and Hypersplenism", in R. Hoffman et al (eds.) Hematology Basic Principles and Practice (Churchill Livingstone) Chapter 125: 1505-1507 (1991).
P. Handagama et al, "Thrombocytopenia and Drugs", Vetern. Clin. of N. Amer.: Small Animal Practice 18(1) 51-65 (1988).
D. F. Stroncek et al, "Quinine-Dependent Antibodies to Neutrophils React With a 60-Kd Glycoprotein on Which Neutrophil-Specific Antigen NB1 is Located . . . ", Blood 81(10): 2758-2766 (1993).
B. C. Gilliland, "Drug-Induced Autoimmune and Hematologic Disorders", Immunology and Allergy Clinics of North America 11(3):525-553 (1991).
G. P. Visentin et al, "Characteristics of Quinine- and Quinine-Induced Antibodies Specific For Platelet Glycoproteins llb and llla", Blood 77(12):2668-2676 (1991).
P. Finley et al "Flow Cytometry Analysis of Platelet Antibodies" in Journal of Clinical Laboratory Analysis vol. 2 No. 4 (1988) pp. 249-255.
D. Christie et al "Detection of Drug-Dependent Platelet Antibodies Using Immobilized Staphylococcal Protein A", Transfusion v. 28. No. 4 (1988) pp. 322-325.
J. Gottschall et al., "Quinine-Induced . . . Thrombocytopenia . . . " Blood, vol. 77, No. 2 (Jan. 15, 1991): pp. 306-310.
Hackh's Chemical Dictionary (fourth edition 1969); pp. 563-564 "Quinidine" and Quinine.
Aster Richard H.
Curtis Brian R.
Spiegel Carol A.
The Blood Center of Southeastern Wisconsin, Inc.
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