Method of detecting cell death and detection reagent

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S004000, C435S007210, C435S007230, C435S007240, C435S007400, C435S007940, C435S025000, C436S518000, C436S536000, C436S086000

Reexamination Certificate

active

07070924

ABSTRACT:
A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in body fluid by a sandwich method and a reagent for measuring cytochrome C for determination cytochrome C in body fluid by a sandwich method, which comprises an antibody directed to cytochrome C as an ingredient.

REFERENCES:
patent: 2002/0192712 (2002-12-01), Endo et al.
patent: 2004/0043435 (2004-03-01), Los et al.
patent: 2005/0106561 (2005-05-01), Suzuki et al.
patent: 2 241 782 (1991-09-01), None
patent: 03-257367 (1991-11-01), None
patent: WO 98/02579 (1998-01-01), None
Gvatua et al, Terapevticheskii Arkhiv, 62 (4), 58-61, 1990.
Gvatua et al, Terapevticheskii Arkhiv, 62 (4), 58-61, 1990 (Abstract). Online, retrieved on Aug. 2, 2005 from STN International. Columbus, OH. Accession No. 1990:445440 BIOSIS.
Hales et al, Methods in Enzymology, 70, 334-335, 1980.
Fujimura, M., et al. “Cytosolic Redistribution of Cytochrome c After Transient Focal Cerebral Ischemia in Rats.”Journal of Cerebral Metabolism, 18:1239-1247, 1998.
Antonawich, “Translocation of Cytochrome c Following Transient Global Ischemia in the Gerbil”,Neuroscience Letters, 274: 123-126, 1999.
Dinsdale, et al., “Redistribution of Cytochrome c Precedes the Caspase-Dependent Formation of Ultracondensed Mitochondria, with a Reduced Inner Membrane Potential, in Apoptotic Monocytes”,American Journal of Pathology, 155(2): 607-618, 1999.
Hetts, “To Die or Not to Die”,JAMA, 279(4): 300-307, 1998.
Jemmerson, et al., “A Monoclonal Antibody Specific for a Cytochrome c T cell Stimulatory Peptide Inhibits T cell Responses and Affects the Way the Peptide Associates with Antigen-Presenting Cells”,European Journal of Immunology, 21: 143-151, 1991.
Los, et al., “Cytochrome c is Rapidly Released from the Cell Upon Apoptosis Induction: A New Marker for Cell Death in vivo”,Immunology Letters, 73(2-3): 239, 2000.
Shounan et al., “Apoptosis Detection by Annexin V Binding: A Novel Method for the Quantitation of Cell-Mediated Cytotoxicity”,Journal of Immunological Methods, 217: 61-70, 1998.
Ushmorov, et al., “Nitric Oxide-Induced Apoptosis in Human Leukemic Lines Requires Mitochondrial Lipid Degradation and Cytochrome C Release”,Blood, 93(7): 2342-2352, 1999.
Copy of European Search Report for related EP application No. 02253172.7.

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