Chemistry: analytical and immunological testing – Metal or metal containing – Present in biological fluids
Patent
1990-08-03
1992-03-17
Lacey, David L.
Chemistry: analytical and immunological testing
Metal or metal containing
Present in biological fluids
436 79, 436166, G01N 3370
Patent
active
050968327
ABSTRACT:
Disclosed is a tetra substituted cyclohexane having an ionophore in the one and two positions wherein the ionophore may be the same or different and is selected from the group consisting of a crown, a podand and a cryptand wherein the ionophore is capable of complexing with a metal or ammonium cation. Positions four and five are substituted by an electron donor group and an electron acceptor group. Also disclosed is a method for detecting the concentration of cations in a fluid by subjecting the fluid to the tetra substituted cyclohexane composition which will thereby complex the cation in the fluid. The cations are preferably alkali metal and alkaline earth metal cations. The fluid may be an aqueous or non-aqueous fluid or body fluids.
REFERENCES:
patent: 4670218 (1987-06-01), Gantzer et al.
patent: 4994395 (1991-02-01), Chapoteau et al.
"Photoresponsive Crown Ethers. 1. Cis-Trnas Isomerism of Azobenzene as a Tool to Enforce Conformational Changes, etc.", Shinkai, S. et al., Am. Chem. Soc. 1980, 102, 5860-5865.
"1,2-Dithia-5,8,11,14-Tetraoxacyclohexadecane, etc", Raban, M. et al., Chem. Soc., Chem. Commun., 1983, 1409.
"Host-Guest Complexation, etc.", Cram; D. J., Brown; B. S., et al., Am. Chem. Soc., 1984, 106.
"`Flipped-Out` Ionophores Trans-Cyclohexano Pentaethylene Glycol Diethyl Ethers"; Raban, M., et al., Chem. Soc., Chem. Common, 1985, 1557.
"Preo-Organization-from Solvents to Spherands", Cram, D. J., Angew. Chem. Int. Ed. Engl., 1986, 25, 1039.
"Host-Guest Complexation. 44. Cavitands and Caviplexes, etc.", Burch, D. L., Master's Thesis, Wayne State University, 1987.
Hortelano, E. R. Doctorial Dissertation, Wayne State University, 1988 re: Switched-On Flipped-Out Ionophores.
Durocher David T.
Raban Morton
Daley Thomas E.
Lacey David L.
Wayne State University
LandOfFree
Method of detecting cations using a tetra substituted cyclohexan does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of detecting cations using a tetra substituted cyclohexan, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of detecting cations using a tetra substituted cyclohexan will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1475556