Chemistry: analytical and immunological testing – Cancer
Patent
1985-05-02
1988-08-30
Marantz, Sidney
Chemistry: analytical and immunological testing
Cancer
128653, 250373, 356 51, 424 3, 435173, 436 63, 436164, G01N 3348
Patent
active
047677171
ABSTRACT:
A method of detecting and quantitating cell malignancy in biological tissue is provided and initially includes preparing a tissue sample having a substantially constant thickness. The tissue sample was impinged by filtered electromagnetic energy within an approximate bandwidth between 255.0-265.0 nm with a preferred wavelength of 260.0 nm. A standard Zeiss microscope was used to observe and measure the nuclear material with the microscope being fitted with quartz optics. The volume of nuclear material being examined was maintained relatively constant by selecting an aperture smaller in diameter than the magnified image of the nucleus being examined in combination with the subtantially uniform thickness of the tissue samples. The electromagnetic energy subsequent to being reflected from the tissue sample was passed through a second optical filter having an approximate filtering capacity in the range of 260.0 nm. The amount of electromagnetic energy within the predetermined bandwidth determined by the filters and absorbed by the nucleate of the cells within the tissue sample was measured. The amount of electromagnetic energy within the predetermined bandwidth absorbed by the nucleate was then quantified showing a higher absorptance of the filtered electromagnetic energy by malignant cells when taken with respect to normal cells.
REFERENCES:
patent: 2708515 (1955-05-01), Bliss
patent: 3327117 (1967-06-01), Kamentsky
patent: 3327119 (1967-06-01), Kamentsky
patent: 3456641 (1969-07-01), Yokota et al.
patent: 3463142 (1969-08-01), Harte
patent: 3497690 (1970-02-01), Wheeless, Sr. et al.
patent: 3505524 (1970-04-01), Hjerten
patent: 3540824 (1968-10-01), Fonda et al.
patent: 3613884 (1971-10-01), Van Gaalen
patent: 3694086 (1972-09-01), May
patent: 3699336 (1972-10-01), Ehrlich et al.
patent: 3740144 (1973-06-01), Walker
patent: 3765775 (1973-10-01), Ganssle et al.
patent: 3824393 (1974-07-01), Brain
patent: 3861788 (1975-01-01), Webster
patent: 3877818 (1975-04-01), Button et al.
patent: 4006360 (1977-02-01), Mueller
patent: 4017192 (1977-04-01), Rosenthal
patent: 4063892 (1977-12-01), Vassileu et al.
patent: 4093381 (1978-06-01), Karamian
patent: 4115802 (1978-09-01), Kramer et al.
patent: 4195225 (1980-03-01), Karamian
patent: 4207892 (1980-06-01), Binder
patent: 4293221 (1981-10-01), Kay et al.
patent: 4350892 (1982-09-01), Kay et al.
Mellors et al (1952), Science, vol. 116, pp. 265-269.
Zworykin et al (1957), Science, vol. 126, No. 3278, pp. 805-810.
Mellors (1950), Science, vol. 112, pp. 381-389.
Marantz Sidney
Rosenberg Morton J.
LandOfFree
Method of detecting and quantitating cell malignancy in biologic does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of detecting and quantitating cell malignancy in biologic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of detecting and quantitating cell malignancy in biologic will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2088090